F
Frédéric Lofaso
Researcher at French Institute of Health and Medical Research
Publications - 251
Citations - 10572
Frédéric Lofaso is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Mechanical ventilation & Breathing. The author has an hindex of 53, co-authored 233 publications receiving 9839 citations. Previous affiliations of Frédéric Lofaso include Versailles Saint-Quentin-en-Yvelines University.
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Journal ArticleDOI
Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease.
Laurent Brochard,Jordi Mancebo,Marc Wysocki,Frédéric Lofaso,Giorgio Conti,Alain Rauss,Gérald Simonneau,Salvador Benito,A. Gasparetto,François Lemaire +9 more
TL;DR: In selected patients with acute exacerbations of chronic obstructive pulmonary disease, noninvasive ventilation can reduce the need for endotracheal intubation, the length of the hospital stay, and the in-hospital mortality rate.
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Ventilatory and hemodynamic effects of continuous positive airway pressure in left heart failure.
TL;DR: In patients with respiratory insufficiency caused by congestive heart failure (CHF), CPAP reduces respiratory muscle effort without altering cardiac output, and the slight decrease in mean transmural left and right atrial pressures suggests an improvement in cardiac performance.
Journal ArticleDOI
Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways
Stéphane Dauger,Alexandre Pattyn,Frédéric Lofaso,Claude Gaultier,Christo Goridis,Jorge Gallego,Jean-François Brunet +6 more
TL;DR: It is reported that the afferent relays of visceral reflexes, differentiate under the control of the paired-like homeobox gene Phox2b: the neural crest-derived carotid body, a chemosensor organ, degenerates in homozygous mutants, as do the three epibranchial placode-derived visceral sensory ganglia (geniculate, petrosal and nodose).
Journal ArticleDOI
Nasal obstruction as a risk factor for sleep apnoea syndrome
Frédéric Lofaso,André Coste,M P D'Ortho,Françoise Zerah-Lancner,Christophe Delclaux,Françoise Goldenberg,Alain Harf +6 more
TL;DR: In this paper, a stepwise multiple regression analysis showed that BMI, male sex, nasal resistance, and cephalometric parameters were contributing factors to obstructive sleep apnoea syndrome (OSAS).
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Expiratory muscle activity increases intrinsic positive end-expiratory pressure independently of dynamic hyperinflation in mechanically ventilated patients.
TL;DR: The drop in Pga and the drop in Pes at end-expiration were synchronous, and these changes were consistent with a concomitant relaxation of the expiratory muscles and activation of the inspiratory muscles.