A
Alexandre Urzhumtsev
Researcher at University of Lorraine
Publications - 53
Citations - 3390
Alexandre Urzhumtsev is an academic researcher from University of Lorraine. The author has contributed to research in topics: Ab initio & Resolution (electron density). The author has an hindex of 19, co-authored 52 publications receiving 2122 citations. Previous affiliations of Alexandre Urzhumtsev include Nancy-Université & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Real-space refinement in PHENIX for cryo-EM and crystallography.
Pavel V. Afonine,Pavel V. Afonine,Billy K. Poon,Randy J. Read,Oleg V. Sobolev,Thomas C. Terwilliger,Alexandre Urzhumtsev,Alexandre Urzhumtsev,Paul D. Adams,Paul D. Adams +9 more
TL;DR: In this article, the authors describe the implementation of real-space refinement in the phenixreal_space-refine program from the PHENIX suite, which makes use of extra information such as secondary-structure and rotamer-specific restraints.
Journal ArticleDOI
New tools for the analysis and validation of cryo-EM maps and atomic models
Pavel V. Afonine,Pavel V. Afonine,Bruno P. Klaholz,Nigel W. Moriarty,Billy K. Poon,Oleg V. Sobolev,Thomas C. Terwilliger,Paul D. Adams,Paul D. Adams,Alexandre Urzhumtsev,Alexandre Urzhumtsev +10 more
TL;DR: New methods and PHENIX tools for quality assessment of cryo-EM maps, atomic models and model-to-map fitting are presented and results of systematic application of these tools to high-resolution cryospecies maps and corresponding atomic models are analyzed and discussed.
Posted ContentDOI
New tools for the analysis and validation of Cryo-EM maps and atomic models
Pavel V. Afonine,Bruno P. Klaholz,Nigel W. Moriarty,Billy K. Poon,Oleg V. Sobolev,Thomas C. Terwilliger,Paul D. Adams,Alexandre Urzhumtsev,Alexandre Urzhumtsev +8 more
TL;DR: It is suggested that cryo-EM half-maps and masks are deposited to facilitate evaluation and validation of cryo -EM derived atomic models and maps.
Journal ArticleDOI
Crystal structure of the 80S yeast ribosome.
Lasse Jenner,Sergey Melnikov,Nicolas Garreau de Loubresse,Adam Ben-Shem,Madina Iskakova,Alexandre Urzhumtsev,Arturas Meskauskas,Arturas Meskauskas,Jonathan D. Dinman,Gulnara Yusupova,Marat Yusupov +10 more
TL;DR: This review will focus on the development of isolation procedures that allowed structure determination (both cryo-EM and X-ray crystallography) to be successful for the yeast S. cerevisiae and introduce a new nomenclature that facilitates comparison of ribosomes from different species and kingdoms of life.
Journal ArticleDOI
Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site
TL;DR: The crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites is solved and the first state of the eukaryotic A site is basically the same as in the bacterial A site with bulging A1492 and A1493.