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Alexandros Mitsios
Researcher at Democritus University of Thrace
Publications - 17
Citations - 1240
Alexandros Mitsios is an academic researcher from Democritus University of Thrace. The author has contributed to research in topics: Neutrophil extracellular traps & Inflammation. The author has an hindex of 11, co-authored 17 publications receiving 661 citations.
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Journal ArticleDOI
Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis.
Panagiotis Skendros,Alexandros Mitsios,Akrivi Chrysanthopoulou,Dimitrios C. Mastellos,Simeon Metallidis,Petros I. Rafailidis,Maria Ntinopoulou,Eleni Sertaridou,Victoria Tsironidou,Christina Tsigalou,Maria G Tektonidou,Theocharis Konstantinidis,Charalampos Papagoras,Ioannis Mitroulis,Georgios Germanidis,John D. Lambris,Konstantinos Ritis +16 more
TL;DR: A mechanistic basis is provided for a pivotal role of complement and NETs in COVID-19 immunothrombosis and supports strategies against SARS-CoV-2 that exploit complement or NETosis inhibition.
Journal ArticleDOI
REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A).
Eleni Frangou,Akrivi Chrysanthopoulou,Alexandros Mitsios,Konstantinos Kambas,Stella Arelaki,Iliana Angelidou,Athanasios Arampatzioglou,Hariklia Gakiopoulou,George Bertsias,Panayotis Verginis,Konstantinos Ritis,Dimitrios T. Boumpas +11 more
TL;DR: Autophagy-mediated release of TF-bearing and IL-17A-bearing NETs provides a link between thromboinflammation and fibrosis in SLE and may account for the salutary effects of hydroxychloroquine.
Journal ArticleDOI
Gradient Infiltration of Neutrophil Extracellular Traps in Colon Cancer and Evidence for Their Involvement in Tumour Growth
Stella Arelaki,Athanasios Arampatzioglou,Konstantinos Kambas,Charalampos Papagoras,Paraskevi Miltiades,Iliana Angelidou,Alexandros Mitsios,Ioannis Kotsianidis,Panagiotis Skendros,Efthimios Sivridis,Ioanna G. Maroulakou,Alexandra Giatromanolaki,Konstantinos Ritis +12 more
TL;DR: The in vitro-generated NETs impeded growth of cancer cell cultures by inducing apoptosis and/or inhibiting proliferation and this data support further the role of neutrophils and NETs in cancer biology.
Journal ArticleDOI
REDD1/Autophagy Pathway Is Associated with Neutrophil-Driven IL-1β Inflammatory Response in Active Ulcerative Colitis.
Iliana Angelidou,Akrivi Chrysanthopoulou,Alexandros Mitsios,Stella Arelaki,Athanasios Arampatzioglou,Konstantinos Kambas,Dimitrios Ritis,Victoria Tsironidou,I Moschos,Vasiliki Dalla,Dimitrios Stakos,Georgios Kouklakis,Ioannis Mitroulis,Konstantinos Ritis,Panagiotis Skendros +14 more
TL;DR: It is shown that neutrophil expression of REDD1 in colon tissue and the presence of IL-1β in neutrophils/NETs provide candidate biomarkers for the differential diagnosis of inflammatory colitis and possible targets for the treatment of UC, suggesting that UC shares common features with autoinflammatory disorders.
Journal ArticleDOI
Interferon lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation
Akrivi Chrysanthopoulou,Konstantinos Kambas,Dimitrios Stakos,Ioannis Mitroulis,Alexandros Mitsios,Veroniki P. Vidali,Iliana Angelidou,Magdalena L. Bochenek,Stella Arelaki,Athanasios Arampatzioglou,Ioanna-Evdokia Galani,Panagiotis Skendros,Elias A. Couladouros,Stavros Konstantinides,Evangelos Andreakos,Katrin Schäfer,Konstantinos Ritis +16 more
TL;DR: The role of IFN‐λ1/IL‐29, a major antiviral cytokine recently shown to suppress the neutrophil migratory capacity, is explored in prothrombotic and proNETotic functions of neutrophils and in an ex vivo human experimental setting of acute ST‐segment elevation myocardial infarction, it is shown that IFN-λ2/IL-28A exerts strong antithrombosis potential.