S
Simeon Metallidis
Researcher at Aristotle University of Thessaloniki
Publications - 79
Citations - 1742
Simeon Metallidis is an academic researcher from Aristotle University of Thessaloniki. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 49 publications receiving 821 citations. Previous affiliations of Simeon Metallidis include AHEPA University Hospital.
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Journal ArticleDOI
Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis.
Panagiotis Skendros,Alexandros Mitsios,Akrivi Chrysanthopoulou,Dimitrios C. Mastellos,Simeon Metallidis,Petros I. Rafailidis,Maria Ntinopoulou,Eleni Sertaridou,Victoria Tsironidou,Christina Tsigalou,Maria G Tektonidou,Theocharis Konstantinidis,Charalampos Papagoras,Ioannis Mitroulis,Georgios Germanidis,John D. Lambris,Konstantinos Ritis +16 more
TL;DR: A mechanistic basis is provided for a pivotal role of complement and NETs in COVID-19 immunothrombosis and supports strategies against SARS-CoV-2 that exploit complement or NETosis inhibition.
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Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial.
Spyridon Deftereos,Georgios Giannopoulos,Dimitrios A. Vrachatis,Gerasimos Siasos,Sotiria G. Giotaki,Panagiotis Gargalianos,Simeon Metallidis,George Sianos,Stefanos Baltagiannis,Periklis Panagopoulos,Konstantinos Dolianitis,Efthalia Randou,Konstantinos N. Syrigos,Anastasia Kotanidou,Nikolaos Koulouris,Haralampos J. Milionis,Nikolaos V. Sipsas,Charalampos Gogos,George Tsoukalas,Christoforos Olympios,Eleftheria P Tsagalou,Ilias Migdalis,Styliani Gerakari,Christos Angelidis,Dimitrios Alexopoulos,Pericles Davlouros,George Hahalis,Ioannis Kanonidis,Demosthenes G. Katritsis,Theofilos M. Kolettis,Antonios S. Manolis,Lampros K. Michalis,Katerina K. Naka,Vlasios Pyrgakis,Konstantinos Toutouzas,Filippos Triposkiadis,Konstantinos Tsioufis,Emmanouil Vavouranakis,Luis Martínez-Dolz,Bernhard Reimers,Giulio G. Stefanini,Michael W. Cleman,John A. Goudevenos,Sotirios Tsiodras,Dimitrios Tousoulis,Efstathios K. Iliodromitis,Roxana Mehran,George Dangas,Christodoulos Stefanadis,Christodoulos Stefanadis +49 more
TL;DR: A role for colchicine in the treatment of patients with coronavirus disease 2019 is suggested, with results suggesting a smaller increase in dimerized plasma fragment D compared with patients in the control group.
Journal ArticleDOI
Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial.
Evdoxia Kyriazopoulou,Garyfallia Poulakou,Haralampos J. Milionis,Simeon Metallidis,Georgios Adamis,Konstantinos Tsiakos,Archontoula Fragkou,Aggeliki Rapti,Christina Damoulari,Massimo Fantoni,Ioannis Kalomenidis,Georgios Chrysos,Andrea Angheben,Ilias Kainis,Zoi Alexiou,Francesco Castelli,Francesco Saverio Serino,Maria Tsilika,Petros Bakakos,Emanuele Nicastri,Vassiliki Tzavara,Evangelos Kostis,Lorenzo Dagna,Panagiotis Koufargyris,Katerina Dimakou,Spyridon Savvanis,Glykeria Tzatzagou,Maria Giovanna Chini,Giulio Cavalli,Matteo Bassetti,Konstantina Katrini,Vasileios Kotsis,George Tsoukalas,Carlo Selmi,Ioannis Bliziotis,Michael Samarkos,Michael Doumas,Sofia Ktena,Aikaterini Masgala,Ilias Papanikolaou,Maria Kosmidou,Dimitra Melia Myrodia,Aikaterini Argyraki,Chiara Simona Cardellino,Katerina Koliakou,Eleni Ioanna Katsigianni,Vassiliki Rapti,Efthymia Giannitsioti,Antonella Cingolani,Styliani Micha,Karolina Akinosoglou,Orestis Liatsis-Douvitsas,Styliani Symbardi,Nikolaos K. Gatselis,Maria Mouktaroudi,Giuseppe Ippolito,Eleni Florou,Antigone Kotsaki,Mihai G. Netea,Mihai G. Netea,Jesper Eugen-Olsen,Miltiades Kyprianou,Periklis Panagopoulos,George N. Dalekos,Evangelos J. Giamarellos-Bourboulis +64 more
TL;DR: The SAVE-MORE trial as discussed by the authors evaluated the efficacy and safety of anakinra, an IL-1α/β inhibitor, in 594 patients with COVID-19 at risk of progressing to respiratory failure.
Journal ArticleDOI
Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial
Mark N. Polizzotto,Jacqueline Nordwall,Abdel Babiker,Andrew N. Phillips,David M. Vock,N. Eriobu,Vivian Kwaghe,Roger Paredes,Lourdes Mateu,Srikanth Ramachandruni,R. Narang,M. Jain,Susana M. Lazarte,Jason V. Baker,Anne E. P. Frosch,Garyphallia Poulakou,Konstantinos N. Syrigos,Gretchen S. Arnoczy,Natalie A. McBride,Philip Robinson,Farjad Sarafian,Sanjay Bhagani,Hassan S. Taha,Thomas Benfield,Sean T. H. Liu,Anastasia Antoniadou,Jens-Ulrik Stæhr Jensen,Ioannis Kalomenidis,Adi Susilo,Prasetyo Hariadi,Tomas O. Jensen MD,José Luis Morales-Rull,Marie Helleberg,Sreenath Meegada,A. Johansen,D. Canario,Eduardo Fernández-Cruz,Simeon Metallidis,Amish C. Shah,Aki Sakurai,Nikolaos Koulouris,Robin Trotman,Amy C. Weintrob,D Podlekareva,Usman Hadi,Kate Lloyd,Birgit Røge,Sho Saito,Kelly A. Sweerus,Jakob J Malin,Christoph Lübbert,Jose Muñoz,Matthew J. Cummings,M. H. Losso,Dan Turner,Kathryn Shaw-Saliba,Robin Dewar,Helene C. Highbarger,Perrine Lallemand,Tauseef ur Rehman,Norman P. Gerry,Dona Arlinda,Christina C. Chang,Birgit Grund,Michael R. Holbrook,H P Holley,Fleur Hudson,Laura A. McNay,Daniel D Murray,Sarah Pett,Megan Shaughnessy,M. Smolskis,Giota Touloumi,Mary Etta Wright,Mittie K. Doyle,Sharon Popik,Christine Hall,Roshan Ramanathan,Huyen Cao,Elsa Mondou,Todd Willis,Joseph V. Thakuria,Leman Yel,Elizabeth S. Higgs,V. Kan,Jens D Lundgren,James D. Neaton,H. Clifford Lane +87 more
TL;DR: When administered with standard of care including remdesivir, SARS-CoV-2 hIVIG did not demonstrate efficacy among patients hospitalised with COVID-19 without end-organ failure and there was evidence of heterogeneity of the treatment effect for the day 7 composite safety outcome.
Journal ArticleDOI
Penetration of Moxifloxacin and Levofloxacin into Cancellous and Cortical Bone in Patients Undergoing Total Hip Arthroplasty
Simeon Metallidis,D. Topsis,John Nikolaidis,E. Alexiadou,Georgia Lazaraki,L. Grovaris,A. Theodoridou,Pavlos Nikolaidis +7 more
TL;DR: The concentrations for both quinolones were above the minimum inhibitory concentration (MIC90s) for the most common pathogens, so they can be used for the treatment of osteomyelitis.