K
Katrin Schäfer
Researcher at University of Mainz
Publications - 108
Citations - 5428
Katrin Schäfer is an academic researcher from University of Mainz. The author has contributed to research in topics: Leptin & Neointima. The author has an hindex of 37, co-authored 102 publications receiving 4661 citations. Previous affiliations of Katrin Schäfer include Max Planck Society & Scripps Research Institute.
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Journal ArticleDOI
Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity
TL;DR: A novel receptor-dependent effect of leptin on platelet function and hemostasis is revealed and new insights are provided into the molecular basis of cardiovascular complications in obese individuals.
Journal ArticleDOI
Differential Cardiac Remodeling in Preload Versus Afterload
Karl Toischer,Adam G. Rokita,Bernhard Unsöld,Wuqiang Zhu,Georgios Kararigas,Samuel Sossalla,Sean Reuter,Alexander Becker,Nils Teucher,Tim Seidler,Cornelia Grebe,Lena Preuß,Shamindra N. Gupta,Kathie Schmidt,Stephan E. Lehnart,Martina Krüger,Wolfgang A. Linke,Johannes Backs,Vera Regitz-Zagrosek,Katrin Schäfer,Loren J. Field,Lars S. Maier,Gerd Hasenfuss +22 more
TL;DR: Afterload results in maladaptive fibrotic hypertrophy with calcium/calmodulin-dependent protein kinase II–dependent altered calcium cycling and apoptosis and indicates that different loads result in distinct phenotype differences that may require specific pharmacological interventions.
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Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Susanne Karbach,Tanja Schönfelder,Inês Brandão,Eivor Wilms,Nives Hörmann,Sven Jäckel,Rebecca Schüler,Stefanie Finger,Maike Knorr,Jeremy Lagrange,Moritz Brandt,Ari Waisman,Sabine Kossmann,Katrin Schäfer,Thomas Münzel,Christoph Reinhardt,Philip Wenzel +16 more
TL;DR: Gut microbiota facilitate AngII‐induced vascular dysfunction and hypertension, at least in part, by supporting an MCP‐1/IL‐17 driven vascular immune cell infiltration and inflammation.
Journal ArticleDOI
Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm.
TL;DR: Data strongly suggest that passive smoking is capable of precipitating acute manifestations of CVD (atherothrombosis) and may also have a negative impact on the outcome of patients who suffer acute coronary syndromes.
Journal ArticleDOI
Leptin Promotes Vascular Remodeling and Neointimal Growth in Mice
Katrin Schäfer,Martin Halle,Colin Goeschen,Claudia Dellas,Marianne Pynn,David J. Loskutoff,Stavros Konstantinides +6 more
TL;DR: The results raise the possibility that there might be a direct, leptin receptor-mediated link between the hyperleptinemia in human obesity and the increased risk for cardiovascular complications associated with this condition.