A
Alexandros Pertsinidis
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 25
Citations - 1075
Alexandros Pertsinidis is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Colloidal crystal & Gene. The author has an hindex of 10, co-authored 22 publications receiving 855 citations. Previous affiliations of Alexandros Pertsinidis include Stanford University & Brown University.
Papers
More filters
Journal ArticleDOI
Subnanometre single-molecule localization, registration and distance measurements
TL;DR: The improved resolution will allow the structure of large, multisubunit biological complexes in biologically relevant environments to be deciphered at the single-molecule level.
Journal ArticleDOI
Diffusion of point defects in two-dimensional colloidal crystals
TL;DR: Evidence that the excitation of point defects into dislocation pairs enhances the diffusion of di-vacancies in two-dimensional colloidal crystals is seen, and the hopping of the defects does not follow a pure random walk, but exhibits surprising memory effects.
Journal ArticleDOI
Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription at Single Genes in Live Cells.
Jieru Li,Ankun Dong,Kamola Saydaminova,Hill Chang,Guanshi Wang,Hiroshi Ochiai,Takashi Yamamoto,Alexandros Pertsinidis +7 more
TL;DR: This work zooming into single tagged genes using nanoscopy techniques, including an active target-locking, ultra-sensitive system that enables single-molecule detection in addressable sub-diffraction volumes, within crowded intracellular environments, sets the stage for single-Molecule studies of complex molecular processes in live cells.
Journal ArticleDOI
Statics and dynamics of 2D colloidal crystals in a random pinning potential.
TL;DR: It is found that the static orientational correlation function g6(r) decays exponentially for intermediate and strong pinning, in agreement with theories.
Journal ArticleDOI
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ
Alexandros Pertsinidis,Alexandros Pertsinidis,Konark Mukherjee,Manu Sharma,Zhiping P. Pang,Sang Ryul Park,Yunxiang Zhang,Axel T. Brunger,Thomas C. Südhof,Steven Chu +9 more
TL;DR: Two-color fluorescence nanoscopy is developed to directly visualize molecular interactions in situ and discovered that syntaxin-1, SNAP-25, and Munc18-1 (mammalian uncoordinated-18), three essential components for neurotransmission, closely colocalize on the plasma membrane, suggesting possible pathways for SNARE-mediated membrane fusion.