A
Alexis Weinreb
Researcher at Yale University
Publications - 8
Citations - 467
Alexis Weinreb is an academic researcher from Yale University. The author has contributed to research in topics: Gene & RNA. The author has an hindex of 3, co-authored 5 publications receiving 95 citations. Previous affiliations of Alexis Weinreb include Vanderbilt University.
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Journal ArticleDOI
Molecular topography of an entire nervous system.
Seth R. Taylor,Gabriel Santpere,Gabriel Santpere,Alexis Weinreb,Alec Barrett,Molly B. Reilly,Molly B. Reilly,Chuan Xu,Erdem Varol,Panos Oikonomou,Panos Oikonomou,Lori Glenwinkel,Lori Glenwinkel,Rebecca McWhirter,Abigail Poff,Manasa Basavaraju,Ibnul Rafi,Ibnul Rafi,Eviatar Yemini,Eviatar Yemini,Steven J. Cook,Steven J. Cook,Alexander J. Abrams,Berta Vidal,Berta Vidal,Cyril Cros,Cyril Cros,Saeed Tavazoie,Saeed Tavazoie,Nenad Sestan,Marc Hammarlund,Oliver Hobert,Oliver Hobert,David M. Miller +33 more
TL;DR: In this paper, the authors have produced gene expression profiles of all 302 neurons of the C. elegans nervous system that match the single-cell resolution of its anatomy and wiring diagram, showing that individual neuron classes can be solely identified by combinatorial expression of specific gene families.
Posted ContentDOI
Molecular topography of an entire nervous system
Seth R. Taylor,Gabriel Santpere,Alexis Weinreb,Alec Barrett,Molly B. Reilly,Molly B. Reilly,Chuan Xu,Erdem Varol,Panos Oikonomou,Panos Oikonomou,Lori Glenwinkel,Lori Glenwinkel,Rebecca McWhirter,Abigail Poff,Manasa Basavaraju,Ibnul Rafi,Ibnul Rafi,Eviatar Yemini,Eviatar Yemini,Steven J. Cook,Steven J. Cook,Alexander J. Abrams,Berta Vidal,Berta Vidal,Cyril Cros,Cyril Cros,Saeed Tavazoie,Saeed Tavazoie,Nenad Sestan,Marc Hammarlund,Oliver Hobert,Oliver Hobert,David M. Miller +32 more
TL;DR: An expression profile of all 302 neurons of the C. elegans nervous system is produced that matches the single cell resolution of its anatomy and wiring diagram and suggests that individual neuron classes can be solely identified by combinatorial expression of specific gene families.
Posted ContentDOI
Expression profiling of the mature C. elegans nervous system by single-cell RNA-Sequencing
Seth R. Taylor,Gabriel Santpere,Molly B. Reilly,Lori Glenwinkel,Abigail Poff,Rebecca McWhirter,Chuan Xu,Alexis Weinreb,Manasa Basavaraju,Steven J. Cook,Alec Barrett,Alexander J. Abrams,Berta Vidal,Cyril Cros,Ibnul Rafi,Nenad Sestan,Marc Hammarlund,Oliver Hobert,David M. Miller +18 more
TL;DR: This work generated single cell transcriptomes for 52,412 neurons that resolve as clusters corresponding to 109 of the canonical 118 neuron classes in the mature hermaphrodite nervous system, and revealed molecular signatures that further subdivide identified classes into specific neuronal subtypes.
Posted ContentDOI
The neuropeptidergic connectome of C. elegans
Lidia Ripoll-Sánchez,Jan Watteyne,HaoSheng Sun,Robert W. Fernandez,Seth R. Taylor,Alexis Weinreb,Marc Hammarlund,David Miller,Oliver Hobert,Isabel Beets,Petra E. Vértes,William R Schafer +11 more
TL;DR: In this paper , the C. elegans neuropeptidergic connectome was generated by integrating single-cell anatomical and gene expression datasets with a biochemical analysis of receptor-ligand interactions, which is characterized by a high connection density, extended signaling cascades, autocrine foci, and a decentralized topology.
Journal ArticleDOI
A head-to-head comparison of ribodepletion and polyA selection approaches for C. elegans low input RNA-sequencing libraries.
Alec Barrett,Rebecca McWhirter,Seth R. Taylor,Alexis Weinreb,David M. Miller,Marc Hammarlund +5 more
TL;DR: In this paper, the authors compared two approaches for building RNAseq libraries from less than 10 nanograms of C. elegans RNA: SMARTSeq V4 (Takara), a widely used kit for selecting poly-adenylated transcripts; and SoLo Ovation (Tecan Genomics), a newly developed ribodepletion-based approach.