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Ali El-Tayeb
Researcher at University of Bonn
Publications - 33
Citations - 1653
Ali El-Tayeb is an academic researcher from University of Bonn. The author has contributed to research in topics: Adenosine & Receptor. The author has an hindex of 20, co-authored 33 publications receiving 1395 citations. Previous affiliations of Ali El-Tayeb include University of Düsseldorf.
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Journal ArticleDOI
Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors.
Thorsten Gnad,Saskia Scheibler,Ivar von Kügelgen,Camilla Scheele,Ana Kilić,Anja Glöde,Linda S. Hoffmann,Laia Reverte-Salisa,Philipp Horn,Samet Mutlu,Ali El-Tayeb,Mathias Kranz,Winnie Deuther-Conrad,Peter Brust,Martin E. Lidell,Matthias J. Betz,Sven Enerbäck,Jürgen Schrader,Gennady G. Yegutkin,Christa E. Müller,Alexander Pfeifer +20 more
TL;DR: It is demonstrated that adenosine–A2A signalling plays an unexpected physiological role in sympathetic BAT activation and protects mice from diet-induced obesity.
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Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling
Karen Maree Knapp,Matthias Zebisch,Matthias Zebisch,Jan Pippel,Ali El-Tayeb,Christa E. Müller,Norbert Sträter +6 more
TL;DR: Crystal structures of the dimeric human e5NT reveal an extensive 114° conformational switch between the open and closed forms of the enzyme, which indicates that structural control of the domain movement determines the selectivity for monophosphate nucleotides.
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Ecto-5′-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions
Elisabete Augusto,Marco Matos,Marco Matos,Jean Sévigny,Ali El-Tayeb,Margaret S. Bynoe,Christa E. Müller,Rodrigo A. Cunha,Jiang-Fan Chen +8 more
TL;DR: CD73 is pointed to as a new target that can fine-tune A2AR activity, and a novel therapeutic target to manipulate A2 AR-mediated control of striatal function and neurodegeneration.
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Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis
Ulrich Flögel,Sandra Burghoff,Peter L. E. M. van Lent,Sebastian Temme,Lisa Galbarz,Zhaoping Ding,Ali El-Tayeb,Sandra Huels,Florian Bönner,Nadine Borg,Christoph Jacoby,Christa E. Müller,Wim B. van den Berg,Jürgen Schrader +13 more
TL;DR: An adenosine A2A receptor agonist (chet-AMP) is built that displays only the anti-inflammatory function in an animal model of rheumatoid arthritis, suggesting that phosphorylated A2AR agonists may serve as a promising new group of drugs for targeted immunotherapy of inflammation.
Journal ArticleDOI
Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors.
TL;DR: A beta,gamma-dichloromethylene modification in the triphosphate chain of 5-bromo-UTP was tolerated by all three receptor subtypes, thus opening up a new strategy to obtain ectonucleotide diphosphohydrolase- and phosphatase-resistant P2Y2, P 2Y4, and P2y6 receptor agonists.