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Alice Dautry-Varsat
Researcher at Pasteur Institute
Publications - 128
Citations - 11087
Alice Dautry-Varsat is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Endocytosis & Receptor. The author has an hindex of 54, co-authored 128 publications receiving 10771 citations. Previous affiliations of Alice Dautry-Varsat include Centre national de la recherche scientifique & European Institute of Oncology.
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Journal ArticleDOI
pH and the recycling of transferrin during receptor-mediated endocytosis
TL;DR: At pH 5.4 apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to the same extent and with the same affinity as does diferric transferrin at pH 7.0.
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Interleukin 2 Receptors and Detergent-Resistant Membrane Domains Define a Clathrin-Independent Endocytic Pathway
Christophe Lamaze,Annick Dujeancourt,Takeshi Baba,Charles G Lo,Alexandre Benmerah,Alice Dautry-Varsat +5 more
TL;DR: Ulastructural and biochemical experiments showed that clathrin-independent endocytosis of IL2 receptors exists constitutively in lymphocytes and is coupled to their association with detergent-resistant membrane domains, and establish that the IL2 receptor is efficiently internalized through this clathin-independent pathway.
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Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.
TL;DR: It is concluded that the low pH in endocytic vesicles is essential for the dissociation of iron from transferrin and its delivery to the cell, but is not required for recycling of transferrin, and presumably of its receptor.
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Inhibition of clathrin-coated pit assembly by an Eps15 mutant.
TL;DR: Results presented here show that EH domains are required for correct coated pit targeting of Eps15 and strongly suggest a role for Eps15 in coated pit assembly and more precisely a role in the docking of AP-2 onto the plasma membrane.
Journal ArticleDOI
Ap-2/eps15 interaction is required for receptor-mediated endocytosis
Alexandre Benmerah,Christophe Lamaze,Bernadette Bègue,Sandra L. Schmid,Alice Dautry-Varsat,Nadine Cerf-Bensussan +5 more
TL;DR: Results show that interaction of Eps15 with AP-2 is required for efficient receptor-mediated endocytosis and thus provide the first evidence that Eps15 is involved in the function of plasma membrane–coated pits.