A
Alexandre Benmerah
Researcher at University of Paris
Publications - 96
Citations - 6591
Alexandre Benmerah is an academic researcher from University of Paris. The author has contributed to research in topics: Cilium & Endocytosis. The author has an hindex of 46, co-authored 90 publications receiving 6068 citations. Previous affiliations of Alexandre Benmerah include Centre national de la recherche scientifique & Sorbonne.
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Journal ArticleDOI
Interleukin 2 Receptors and Detergent-Resistant Membrane Domains Define a Clathrin-Independent Endocytic Pathway
Christophe Lamaze,Annick Dujeancourt,Takeshi Baba,Charles G Lo,Alexandre Benmerah,Alice Dautry-Varsat +5 more
TL;DR: Ulastructural and biochemical experiments showed that clathrin-independent endocytosis of IL2 receptors exists constitutively in lymphocytes and is coupled to their association with detergent-resistant membrane domains, and establish that the IL2 receptor is efficiently internalized through this clathin-independent pathway.
Journal ArticleDOI
Inhibition of clathrin-coated pit assembly by an Eps15 mutant.
TL;DR: Results presented here show that EH domains are required for correct coated pit targeting of Eps15 and strongly suggest a role for Eps15 in coated pit assembly and more precisely a role in the docking of AP-2 onto the plasma membrane.
Journal ArticleDOI
Ap-2/eps15 interaction is required for receptor-mediated endocytosis
Alexandre Benmerah,Christophe Lamaze,Bernadette Bègue,Sandra L. Schmid,Alice Dautry-Varsat,Nadine Cerf-Bensussan +5 more
TL;DR: Results show that interaction of Eps15 with AP-2 is required for efficient receptor-mediated endocytosis and thus provide the first evidence that Eps15 is involved in the function of plasma membrane–coated pits.
Journal ArticleDOI
The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia
Anahi Molla-Herman,Rania Ghossoub,Rania Ghossoub,Thierry Blisnick,Alice Meunier,Catherine Serres,Catherine Serres,Flora Silbermann,Flora Silbermann,Chris Emmerson,Chris Emmerson,Kelly Romeo,Kelly Romeo,Pierre Bourdoncle,Pierre Bourdoncle,Alain Schmitt,Alain Schmitt,Sophie Saunier,Sophie Saunier,Nathalie Spassky,Philippe Bastin,Alexandre Benmerah,Alexandre Benmerah +22 more
TL;DR: The first detailed characterisation of the ciliary pocket is reported, a depression of the plasma membrane in which the primary cilium is rooted that is enriched in active and dynamic clathrin-coated pits and highlights the conserved role of membrane trafficking in the vicinity of cilia.
Journal ArticleDOI
Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.
Eva M. Schmid,Marijn G. J. Ford,Anne Burtey,Gerrit J. K. Praefcke,Sew-Yeu Peak-Chew,Ian G. Mills,Alexandre Benmerah,Harvey T. McMahon +7 more
TL;DR: It is proposed that clathrin, which interacts with the β-appendage, achieves ligand displacement in vivo by self-polymerisation as the coated pit matures, which changes the interaction environment from liquid-phase, affinity-driven interactions, to interactions driven by solid-phase stability (“matricity”).