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Bernadette Bègue
Researcher at Paris Descartes University
Publications - 32
Citations - 2771
Bernadette Bègue is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Inflammatory bowel disease & Fusion protein. The author has an hindex of 21, co-authored 32 publications receiving 2553 citations. Previous affiliations of Bernadette Bègue include French Institute of Health and Medical Research & University of Paris.
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Journal ArticleDOI
Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease.
Jean-Jacques Mention,Melika Ben Ahmed,Bernadette Bègue,Ullah Barbe,Virginie Verkarre,Virginie Verkarre,Vahid Asnafi,Jean-Frederic Colombel,Paul Henri Cugnenc,Frank M. Ruemmele,Elisabeth Mcintyre,Nicole Brousse,Nicole Brousse,Chistophe Cellier,Nadine Cerf-Bensussan +14 more
TL;DR: Data provide strong evidence that uncontrolled overexpression of IL-15 in refractory celiac sprue perpetuates epithelial damage and promotes the emergence of T-cell clonal proliferations.
Journal ArticleDOI
Ap-2/eps15 interaction is required for receptor-mediated endocytosis
Alexandre Benmerah,Christophe Lamaze,Bernadette Bègue,Sandra L. Schmid,Alice Dautry-Varsat,Nadine Cerf-Bensussan +5 more
TL;DR: Results show that interaction of Eps15 with AP-2 is required for efficient receptor-mediated endocytosis and thus provide the first evidence that Eps15 is involved in the function of plasma membrane–coated pits.
Journal ArticleDOI
Defective IL10 Signaling Defining a Subgroup of Patients With Inflammatory Bowel Disease
Bernadette Bègue,Julien Verdier,Frédéric Rieux-Laucat,Olivier Goulet,A. Morali,Danielle Canioni,Jean-Pierre Hugot,Cécile Daussy,Virginie Verkarre,Bénédicte Pigneur,Alain Fischer,Christoph Klein,Nadine Cerf-Bensussan,Frank M. Ruemmele +13 more
TL;DR: In this article, the capacities of transforming growth factor β (TGFβ) and IL10 to inhibit proinflammatory cytokine production by monocyte-derived dendritic cells (MoDC) or peripheral blood cells (PBMC) was analyzed in 75 children with IBD, including 13 infants with EO-IBD (in which autoimmune diseases or classical immunodeficiencies were ruled out).
Journal ArticleDOI
In Vitro and ex Vivo Activation of the TLR5 Signaling Pathway in Intestinal Epithelial Cells by a Commensal Escherichia coli Strain
Jean-Christophe Bambou,Antoine Giraud,Sandrine Ménard,Bernadette Bègue,Sabine Rakotobe,Sabine Rakotobe,Martine Heyman,François Taddei,Nadine Cerf-Bensussan,Valérie Gaboriau-Routhiau,Valérie Gaboriau-Routhiau +10 more
TL;DR: Findings provide strong evidence that flagellin released by flageLLated commensal bacteria in the intestinal lumen can induce a pro-inflammatory response in enterocytes in vivo.
Journal ArticleDOI
The Ear of α-Adaptin Interacts with the COOH-terminal Domain of the Eps15 Protein
TL;DR: The data indicate that this specific part of AP-2 binds to a cellular component and provide the tools for investigating the function(s) of the association betweenAP-2 and Eps15.