A
Alina Casian
Researcher at Guy's Hospital
Publications - 14
Citations - 909
Alina Casian is an academic researcher from Guy's Hospital. The author has contributed to research in topics: Vasculitis & Systemic vasculitis. The author has an hindex of 9, co-authored 11 publications receiving 596 citations. Previous affiliations of Alina Casian include Population Health Research Institute & MRC Human Nutrition Research.
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Journal ArticleDOI
Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
Michael Walsh,Peter A. Merkel,Chen-Au Peh,Wladimir Szpirt,Xavier Puéchal,Shouichi Fujimoto,Carmel M. Hawley,Nader Khalidi,Oliver Floßmann,Ron Wald,Louis Girard,Adeera Levin,Gina Gregorini,Lorraine Harper,William F. Clark,Christian Pagnoux,Ulrich Specks,Lucy Smyth,Vladimir Tesar,Toshiko Ito-Ihara,Toshiko Ito-Ihara,Janak de Zoysa,Wojciech Szczeklik,Luis Felipe Flores-Suárez,Simon Carette,L. Guillevin,Charles D. Pusey,Alina Casian,Biljana Brezina,Andrea Mazzetti,Carol A. McAlear,Elizabeth Broadhurst,Donna Reidlinger,Samir Mehta,Natalie Ives,David Jayne,Pexivas Investigators Pexivas Investigators +36 more
TL;DR: Among patients with severe ANCA-associated vasculitis, the use of plasma exchange did not reduce the incidence of death or ESKD, and a reduced-dose regimen of glucocorticoids was noninferior to a standard- dose regimen with respect to death orESKD.
Journal ArticleDOI
Long-term follow-up of patients with severe ANCA-associated vasculitis comparing plasma exchange to intravenous methylprednisolone treatment is unclear
Michael Walsh,Alina Casian,Oliver Flossmann,Kerstin Westman,Peter Höglund,Charles D. Pusey,David Jayne +6 more
TL;DR: Although short-term results with PLEX are encouraging, the long-term benefits remain unclear, and further research is required to determine the role of PLEx in AAV.
Journal ArticleDOI
Plasma exchange in the treatment of Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and renal limited vasculitis.
Alina Casian,David Jayne +1 more
TL;DR: PLEX remains a nonselective, expensive therapy with common adverse events, and it is unclear at what severity of renal failure PLEX is beneficial, the optimal PLEx dosing and type and dosing of concomitant medications.
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Intravenous Cyclophosphamide and Plasmapheresis in Dialysis-Dependent ANCA-Associated Vasculitis
Ruth J. Pepper,Ruth J. Pepper,Dimitrios Chanouzas,Ruth M. Tarzi,Mark A. Little,Alina Casian,Michael Walsh,Charles D. Pusey,Lorraine Harper,Alan D. Salama +9 more
TL;DR: Intravenous CYP used with corticosteroids and plasmapheresis may be an effective alternative to oral CYP in patients with dialysis-dependent AAV.
Journal ArticleDOI
Management of alveolar hemorrhage in lung vasculitides.
Alina Casian,David Jayne +1 more
TL;DR: Alveolar hemorrhage is an important pulmonary manifestation of small vessel vasculitis because severe presentations are the most common vasculitic cause of early death and intensive therapy is of particular importance to reduce early mortality and improve longer-term outcomes.