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Wladimir Szpirt
Researcher at University of Copenhagen
Publications - 26
Citations - 1457
Wladimir Szpirt is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Vasculitis & Medicine. The author has an hindex of 9, co-authored 19 publications receiving 804 citations. Previous affiliations of Wladimir Szpirt include Copenhagen University Hospital.
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Journal ArticleDOI
Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
Michael Walsh,Peter A. Merkel,Chen-Au Peh,Wladimir Szpirt,Xavier Puéchal,Shouichi Fujimoto,Carmel M. Hawley,Nader Khalidi,Oliver Floßmann,Ron Wald,Louis Girard,Adeera Levin,Gina Gregorini,Lorraine Harper,William F. Clark,Christian Pagnoux,Ulrich Specks,Lucy Smyth,Vladimir Tesar,Toshiko Ito-Ihara,Toshiko Ito-Ihara,Janak de Zoysa,Wojciech Szczeklik,Luis Felipe Flores-Suárez,Simon Carette,L. Guillevin,Charles D. Pusey,Alina Casian,Biljana Brezina,Andrea Mazzetti,Carol A. McAlear,Elizabeth Broadhurst,Donna Reidlinger,Samir Mehta,Natalie Ives,David Jayne,Pexivas Investigators Pexivas Investigators +36 more
TL;DR: Among patients with severe ANCA-associated vasculitis, the use of plasma exchange did not reduce the incidence of death or ESKD, and a reduced-dose regimen of glucocorticoids was noninferior to a standard- dose regimen with respect to death orESKD.
Journal ArticleDOI
Immunopathogenesis and treatment of cytokine storm in COVID-19.
Jaeseok Kim,Jun Young Lee,Jae Won Yang,Keum Hwa Lee,Maria Effenberger,Wladimir Szpirt,Andreas Kronbichler,Jae Il Shin +7 more
TL;DR: The potential therapeutic role of extracorporeal cytokine removal to treat the cytokine storm associated with COVID-19 is discussed and expectations are especially high for new cytokine-targeted therapies, such as tocilizumab, anakinra, and baricitinib.
Journal ArticleDOI
Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS): protocol for a randomized controlled trial
Michael Walsh,Peter A. Merkel,Chen Au Peh,Wladimir Szpirt,Loïc Guillevin,Charles D. Pusey,Janak deZoysa,Natalie Ives,William F. Clark,Karen Quillen,Jeffrey L. Winters,Keith Wheatley,David Jayne +12 more
TL;DR: This is the largest trial in AAV undertaken to date and will inform the future standard of care for patients with severe AAV, and the cooperation between investigators, funding agencies, and industry provides a model for conducting studies in rare diseases.
Journal ArticleDOI
Plasma exchange for renal vasculitis and idiopathic rapidly progressive glomerulonephritis: a meta-analysis
Michael Walsh,Fausta Catapano,Wladimir Szpirt,Kristian Thorlund,Annette Bruchfeld,Loïc Guillevin,Marion Haubitz,Peter A. Merkel,Chen Au Peh,Charles D. Pusey,David Jayne +10 more
TL;DR: Plasma exchange may decrease the composite end point of end-stage renal disease or death in patients with renal vasculitis, and additional trials are required given the limited data available.
Journal ArticleDOI
Plasma exchange for induction and cyclosporine A for maintenance of remission in Wegener’s granulomatosis—a clinical randomized controlled trial
TL;DR: Renal survival after 1, 3 and 12 months, and 5 years was significantly better in the PE groups, and Multivariate analysis demonstrated that PE improved renal survival at initial plasma creatinine levels >250 µmol/L (2.85 mg/dL).