A
Aline Caroline da Silva
Researcher at Oswaldo Cruz Foundation
Publications - 16
Citations - 453
Aline Caroline da Silva is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Benznidazole & Trypanosoma cruzi. The author has an hindex of 10, co-authored 15 publications receiving 355 citations.
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Journal ArticleDOI
In vitro antileishmanial activity and cytotoxicity of essential oil from Lippia sidoides Cham.
Maria das Graças Freire de Medeiros,Aline Caroline da Silva,Antônia Maria das Graças Lopes Citó,Andrezza Raposo Borges,Sidney Gonçalo de Lima,José Arimatéia Dantas Lopes,Regina Celia Bressan Queiroz de Figueiredo +6 more
TL;DR: The LSEO's activity against both promastigote and the amstigote forms of L. amazonensis, together with its low toxicity to mammalian cells, point to LSEO as a promising agent for the treatment of cutaneous leishmaniasis.
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Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death
Diogo Rodrigo Magalhães Moreira,Ana Daura T. de Oliveira,Paulo André Teixeira de Moraes Gomes,Carlos A. de Simone,Filipe Silva Villela,Rafaela Salgado Ferreira,Aline Caroline da Silva,Thiago André Ramos dos Santos,Maria Carolina Accioly Brelaz de Castro,Valéria Rêgo Alves Pereira,Ana Cristina Lima Leite +10 more
TL;DR: The structural design executed within the series of aryl thiosemicarbazones (9a-x) led to the identification of new potent anti-T.
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Evaluation of the Anti-Schistosoma mansoni Activity of Thiosemicarbazones and Thiazoles
Edna de Farias Santiago,Edna de Farias Santiago,Sheilla Andrade de Oliveira,Gevânio Bezerra de Oliveira Filho,Diogo Rodrigo Magalhães Moreira,Paulo André Teixeira de Moraes Gomes,Anekécia Lauro Da Silva,Andréia Ferreira de Barros,Aline Caroline da Silva,Thiago André Ramos dos Santos,Valéria Rêgo Alves Pereira,Gabriel Gazzoni Araújo Gonçalves,Fábio André Brayner,Luiz Carlos Alves,Almir Gonçalves Wanderley,Ana Cristina Lima Leite +15 more
TL;DR: According to the present study, phthalyl thiazole compounds possess antischistosomal activities and should form the basis for future experimental and clinical trials.
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Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells.
Thiago André Ramos dos Santos,Aline Caroline da Silva,Elany Barbosa da Silva,Paulo André Teixeira de Moraes Gomes,José Wanderlan Pontes Espíndola,Marcos Veríssimo de Oliveira Cardoso,Diogo Rodrigo Magalhães Moreira,Ana Cristina Lima Leite,Valéria Rêgo Alves Pereira +8 more
TL;DR: These 1,3-thiazole and thiosemicarbazone compounds not only exhibited cytotoxicity in cancer cells, but were able to cause irreversible cancer cell damage by inducing necrosis and apoptosis.
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New 1,3-thiazole derivatives and their biological and ultrastructural effects on Trypanosoma cruzi
Paulo André Teixeira de Moraes Gomes,Miria de Oliveira Barbosa,Edna de Farias Santiago,Marcos Veríssimo de Oliveira Cardoso,Natáli Tereza Capistrano Costa,Marcelo Zaldini Hernandes,Diogo Rodrigo Magalhães Moreira,Aline Caroline da Silva,Thiago André Ramos dos Santos,Valéria Rêgo Alves Pereira,Fábio André Brayner dos Santosd,Glaécia Aparecida do Nascimento Pereira,Rafaela Salgado Ferreira,Ana Cristina Lima Leite +13 more
TL;DR: As observed by electron microscopy, compound (1c) treatment caused irreversible and specific morphological changes on ultrastructure organization of T. cruzi, demonstrating that this class of compounds is killing parasites.