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Aline Fréville
Researcher at University of Nottingham
Publications - 20
Citations - 230
Aline Fréville is an academic researcher from University of Nottingham. The author has contributed to research in topics: Plasmodium falciparum & Phosphatase. The author has an hindex of 8, co-authored 13 publications receiving 162 citations. Previous affiliations of Aline Fréville include University of Lille Nord de France & Pasteur Institute.
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Journal ArticleDOI
Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy
Aline Fréville,Katia Cailliau-Maggio,Christine Pierrot,Géraldine Tellier,Hadidjatou Kalamou,Sophia Lafitte,Alain Martoriati,Raymond J. Pierce,Jean-François Bodart,Jamal Khalife +9 more
TL;DR: Biochemical, in vitro and in vivo studies revealed that PfI2 binds PP1 and inhibits its activity, and structure-activity studies of this regulator led to the identification of peptides with anti-plasmodial activity against blood stage parasites in vitro suggesting that PP1c-regulator interactions could be a novel means to control malaria.
Journal ArticleDOI
Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis
Richard J. Wall,Richard J. Wall,David J. P. Ferguson,Aline Fréville,Blandine Franke-Fayard,Declan Brady,Mohammad Zeeshan,Andrew R. Bottrill,Sally P. Wheatley,Andrew M. Fry,Chris J. Janse,Hiroyuki Yamano,Anthony A. Holder,David S. Guttery,Rita Tewari +14 more
TL;DR: The data suggest that Plasmodium utilises unique cell cycle machinery to coordinate various processes during endomitosis, and this warrants further investigation in future studies.
Journal ArticleDOI
Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission
Rajan Pandey,Steven Abel,Matthew Boucher,Richard J. Wall,Mohammad Zeeshan,Edward Rea,Aline Fréville,Xueqing Maggie Lu,Declan Brady,Emilie Daniel,Rebecca R. Stanway,Sally P. Wheatley,Gayani Batugedara,Thomas Hollin,Andrew R. Bottrill,Dinesh Gupta,Anthony A. Holder,Karine G. Le Roch,Rita Tewari +18 more
TL;DR: The role of SMC2 and SMC4, the core subunits of condensin, during endomitosis in schizogony and endoreduplication in male gametogenesis is examined.
Journal ArticleDOI
Plasmodium falciparum Inhibitor-3 Homolog Increases Protein Phosphatase Type 1 Activity and Is Essential for Parasitic Survival
Aline Fréville,Isabelle Landrieu,M. Adelaida García-Gimeno,Jérôme Vicogne,Muriel Montbarbon,Benjamin Bertin,Alexis Verger,Hadidjatou Kalamou,Pascual Sanz,Elisabeth Werkmeister,Christine Pierrot,Jamal Khalife +11 more
TL;DR: Reverse genetic approaches suggest an essential role of PfI3 in the growth and/or survival of blood stage parasites because attempts to obtain knock-out parasites were unsuccessful, although the locus of Pfi3 is accessible.
Journal Article
Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis (vol 8, 5610, 2018)
Richard J. Wall,David J. P. Ferguson,Aline Fréville,Blandine Franke-Fayard,Declan Brady,Mohammad Zeeshan,Andrew R. Bottrill,Sally P. Wheatley,Andrew M. Fry,Chris J. Janse,Hiroyuki Yamano,Anthony A. Holder,David S. Guttery,Rita Tewari +13 more
TL;DR: In this article, the authors examined the localisation and function of APC3 in Plasmodium berghei using reverse genetics and found that APC 3 was observed as a single focus that co-localised with the centriolar plaque during asexual cell division in schizonts and multiple foci in male gametocytes.