A
Alison E. Twelvetrees
Researcher at University of Sheffield
Publications - 18
Citations - 1826
Alison E. Twelvetrees is an academic researcher from University of Sheffield. The author has contributed to research in topics: Dynein & Neurotransmission. The author has an hindex of 11, co-authored 17 publications receiving 1515 citations. Previous affiliations of Alison E. Twelvetrees include University of Pennsylvania & London Research Institute.
Papers
More filters
Journal ArticleDOI
Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses
Andrew F. MacAskill,Johanne Egge Rinholm,Alison E. Twelvetrees,I. Lorena Arancibia-Carcamo,James Muir,Åsa Fransson,Pontus Aspenström,David Attwell,Josef T. Kittler +8 more
TL;DR: It is shown that the protein Miro1 links mitochondria to KIF5 motor proteins, allowing mitochondaria to move along microtubules, and this linkage is inhibited by micromolar levels of Ca2+ binding to Miro 1.
Journal ArticleDOI
Axonal transport: cargo-specific mechanisms of motility and regulation
TL;DR: An overview of axonal transport pathways is provided and their role in neuronal function is discussed and Retrograde transport, which plays a major role in neurotrophic and injury response signaling, is discussed.
Journal ArticleDOI
Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.
Alison E. Twelvetrees,Eunice Y. Yuen,I. Lorena Arancibia-Carcamo,Andrew F. MacAskill,Philippe Rostaing,Michael J. Lumb,Sandrine Humbert,Antoine Triller,Frédéric Saudou,Zhen Yan,Josef T. Kittler +10 more
TL;DR: It is demonstrated that GABA(A)Rs are trafficked to synapses by the kinesin family motor protein 5 (KIF5), and the adaptor linking the receptors to KIF5 as the huntingtin-associated protein 1 (HAP1).
Journal ArticleDOI
The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1
Alison E. Twelvetrees,Stefano Pernigo,Anneri Sanger,Pedro Guedes-Dias,Giampietro Schiavo,Roberto A. Steiner,Mark P. Dodding,Erika L.F. Holzbaur +7 more
TL;DR: This work demonstrates that the outward transport of dynein from soma to axon terminal is driven by direct interactions with the anterograde motor kinesin-1, and proposes a new model for the slow axonal transport of cytosolic cargos, based on short-lived direct interactions of cargo with a highly processive anterOGrade motor.
Journal ArticleDOI
TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation
Adriana R. Mantegazza,Allison L. Zajac,Alison E. Twelvetrees,Erika L.F. Holzbaur,Sebastian Amigorena,Michael S. Marks +5 more
TL;DR: The data show that phagosomal tubules in DCs are functionally distinct from those that emerge from lysosomes and are unique adaptations of the phagocytic machinery that facilitate cargo exchange and antigen presentation among TLR-signaling phagosomes.