A
Alix M. B. Lacoste
Researcher at IBM
Publications - 18
Citations - 993
Alix M. B. Lacoste is an academic researcher from IBM. The author has contributed to research in topics: Biological neural network & Neuron. The author has an hindex of 8, co-authored 17 publications receiving 603 citations. Previous affiliations of Alix M. B. Lacoste include Harvard University.
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Journal ArticleDOI
Whole-brain activity mapping onto a zebrafish brain atlas
Owen Randlett,Caroline Lei Wee,Eva A. Naumann,Eva A. Naumann,Onyeka Nnaemeka,David Schoppik,David Schoppik,James E. Fitzgerald,Ruben Portugues,Alix M. B. Lacoste,Clemens Riegler,Clemens Riegler,Florian Engert,Alexander F. Schier +13 more
TL;DR: An expandable open-source atlas containing molecular labels and definitions of anatomical regions, the Z-Brain, is built to create and contextualize whole-brain maps of stimulus- and behavior-dependent neural activity in zebrafish.
Journal ArticleDOI
Applications of machine learning to diagnosis and treatment of neurodegenerative diseases
Monika A Myszczynska,Poojitha N. Ojamies,Alix M. B. Lacoste,Daniel Neil,Amir Saffari,Richard J. Mead,Guillaume M. Hautbergue,Joanna D. Holbrook,Laura Ferraiuolo +8 more
TL;DR: How machine learning can aid early diagnosis and interpretation of medical images as well as the discovery and development of new therapies is discussed, and the latest developments in the use of machine learning to interrogate neurodegenerative disease-related datasets are described.
Journal ArticleDOI
Artificial intelligence in neurodegenerative disease research: use of IBM Watson to identify additional RNA-binding proteins altered in amyotrophic lateral sclerosis
Nadine Bakkar,Tina Kovalik,Ileana Lorenzini,Scott Spangler,Alix M. B. Lacoste,Kyle Sponaugle,Philip Ferrante,Elenee Argentinis,Rita Sattler,Robert Bowser +9 more
TL;DR: Overall, IBM Watson was successfully used to help identify additional RBPs altered in ALS, highlighting the use of artificial intelligence tools to accelerate scientific discovery in ALS and possibly other complex neurological disorders.
Journal ArticleDOI
A Convergent and Essential Interneuron Pathway for Mauthner-Cell-Mediated Escapes
Alix M. B. Lacoste,David Schoppik,Drew N. Robson,Martin Haesemeyer,Ruben Portugues,Jennifer M. Li,Owen Randlett,Caroline Lei Wee,Florian Engert,Alexander F. Schier +9 more
TL;DR: It is revealed that spiral fiber neurons are essential for the function of the M-cell in response to sensory cues and suggested that convergent excitatory inputs that differ in their input location and timing ensure reliable activation of theM-cell, a feedforward excitatories motif that may extend to other neural circuits.
Journal ArticleDOI
Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets
Caroline Lei Wee,Maxim Nikitchenko,Wei-Chun Wang,Sasha J. Luks-Morgan,Erin Song,James A. Gagnon,James A. Gagnon,Owen Randlett,Isaac H. Bianco,Isaac H. Bianco,Alix M. B. Lacoste,Elena Glushenkova,Joshua P. Barrios,Alexander F. Schier,Sam Kunes,Florian Engert,Adam D. Douglass +16 more
TL;DR: It is shown that noxious stimuli elicit intense and widespread activity in zebrafish oxytocin neurons, which promote defensive behavior by activating hindbrain premotor neurons.