G
Guillaume M. Hautbergue
Researcher at University of Sheffield
Publications - 74
Citations - 4024
Guillaume M. Hautbergue is an academic researcher from University of Sheffield. The author has contributed to research in topics: RNA & C9orf72. The author has an hindex of 30, co-authored 66 publications receiving 3308 citations. Previous affiliations of Guillaume M. Hautbergue include École Normale Supérieure & University of Manchester.
Papers
More filters
Journal ArticleDOI
A simple method for improving protein solubility and long-term stability.
TL;DR: It is demonstrated here that simultaneous addition of charged amino acids L-Arg and L-Glu at 50 mM to the buffer can dramatically increase the maximum achievable concentration of soluble protein (up to 8.7 times), which is particularly suitable for situations where high protein concentration and long-term stability are required.
Journal ArticleDOI
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.
Christopher P. Webster,Emma F. Smith,Claudia S. Bauer,Annekathrin Moller,Guillaume M. Hautbergue,Laura Ferraiuolo,Monika A Myszczynska,Adrian Higginbottom,Matthew J. Walsh,Alexander J. Whitworth,Brian K. Kaspar,Kathrin Meyer,Pamela J. Shaw,Andrew J. Grierson,Kurt J. De Vos +14 more
TL;DR: The data identify C9orf72 as a novel Rab1a effector in the regulation of autophagy and indicate that C 9orf72 haploinsufficiency and associated reductions in Autophagy might be the underlying cause of C9ALS/FTD‐associated p62 pathology.
Journal ArticleDOI
Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.
Johnathan Cooper-Knock,Matthew J. Walsh,Adrian Higginbottom,J. Robin Highley,Mark J. Dickman,Dieter Edbauer,Paul G. Ince,Stephen B. Wharton,Stuart A. Wilson,Janine Kirby,Guillaume M. Hautbergue,Pamela J. Shaw +11 more
TL;DR: Using RNA pulldown and immunohistochemistry in ALS biosamples, Cooper-Knock et al. identify proteins that bind to the repeat expansions in C9orf72 that cause familial amyotrophic lateral sclerosis and frontotemporal dementia.
Journal ArticleDOI
Applications of machine learning to diagnosis and treatment of neurodegenerative diseases
Monika A Myszczynska,Poojitha N. Ojamies,Alix M. B. Lacoste,Daniel Neil,Amir Saffari,Richard J. Mead,Guillaume M. Hautbergue,Joanna D. Holbrook,Laura Ferraiuolo +8 more
TL;DR: How machine learning can aid early diagnosis and interpretation of medical images as well as the discovery and development of new therapies is discussed, and the latest developments in the use of machine learning to interrogate neurodegenerative disease-related datasets are described.
Journal ArticleDOI
Ribosome-inactivating proteins Potent poisons and molecular tools
TL;DR: This review compares archetypal RIP family members with other potent toxins that abolish protein synthesis: the fungal ribotoxins which directly cleave the 28S rRNA and the newly discovered Burkholderia lethal factor 1 (BLF1).