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Allison L. Richards
Researcher at Wayne State University
Publications - 21
Citations - 1030
Allison L. Richards is an academic researcher from Wayne State University. The author has contributed to research in topics: Regulation of gene expression & Gene. The author has an hindex of 10, co-authored 21 publications receiving 856 citations. Previous affiliations of Allison L. Richards include University of Pennsylvania & University of Chicago.
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Journal ArticleDOI
Widespread RNA and DNA sequence differences in the human transcriptome.
Mingyao Li,Isabel X. Wang,Yun Li,Alan Bruzel,Allison L. Richards,Jonathan M. Toung,Vivian G. Cheung,Vivian G. Cheung +7 more
TL;DR: Mass spectrometry detected peptides that are translated from the discordant RNA sequences and thus do not correspond exactly to the DNA sequences in the human transcriptome.
Journal ArticleDOI
Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes.
Joseph C. Maranville,Francesca Luca,Allison L. Richards,Xiaoquan Wen,David B. Witonsky,Shaneen S. Baxter,Matthew Stephens,Anna Di Rienzo +7 more
TL;DR: An initial assessment of variability in the cellular response to GC treatment is provided by profiling gene expression and protein secretion in 114 EBV-transformed B lymphocytes of African and European ancestry and found that genetic variation affects the response of nearby genes and exhibits distinctive patterns of genotype-treatment interactions.
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High-throughput allele-specific expression across 250 environmental conditions.
Gregory A Moyerbrailean,Allison L. Richards,Daniel Kurtz,Cynthia A Kalita,Gordon O Davis,Chris T Harvey,Adnan Alazizi,Donovan Watza,Yoram Sorokin,Nancy J Hauff,Xiang Zhou,Xiaoquan Wen,Roger Pique-Regi,Francesca Luca +13 more
TL;DR: The results demonstrate that comprehensive catalogs of GxE interactions are indispensable to thoroughly annotate genes and bridge epidemiological and genome-wide association studies.
Journal ArticleDOI
Gut microbiota has a widespread and modifiable effect on host gene regulation
Allison L. Richards,Amanda L. Muehlbauer,Adnan Alazizi,Michael B. Burns,Anthony S Findley,Francesco Messina,Trevor J. Gould,Camilla Cascardo,Roger Pique-Regi,Ran Blekhman,Francesca Luca +10 more
TL;DR: The results suggest that specific microbes play an important role in regulating expression of individual host genes involved in human complex traits.
Journal ArticleDOI
RNA-DNA Differences Are Generated in Human Cells within Seconds after RNA Exits Polymerase II
Isabel X. Wang,Leighton J. Core,Hojoong Kwak,Lauren K. Brady,Alan Bruzel,Lee D. McDaniel,Allison L. Richards,Ming Wu,Christopher Grunseich,John T. Lis,Vivian G. Cheung,Vivian G. Cheung +11 more
TL;DR: The results show that RDDs begin to occur in RNA chains ~55 nt from the RNA polymerase II (Pol II) active site, identifying sequence substitution as an early step in cotranscriptional RNA processing.