A
Alma Martelli
Researcher at University of Pisa
Publications - 131
Citations - 3421
Alma Martelli is an academic researcher from University of Pisa. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 31, co-authored 111 publications receiving 2463 citations.
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Journal ArticleDOI
Hydrogen sulphide: novel opportunity for drug discovery
Alma Martelli,Lara Testai,Maria Cristina Breschi,Corrado Blandizzi,Agostino Virdis,Stefano Taddei,Vincenzo Calderone +6 more
TL;DR: Hydrogen sulphide (H2S) is emerging as an important endogenous modulator, which exhibits the beneficial effects of nitric oxide (NO) on the cardiovascular system, without producing toxic metabolites, and several authors look at this mediator as “the new NO” that has given attractive opportunities to develop innovative classes of drugs.
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Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo
Alma Martelli,Lara Testai,Valentina Citi,Alice Marino,Isabella Pugliesi,Elisabetta Barresi,Giulia Nesi,Simona Rapposelli,Sabrina Taliani,Federico Da Settimo,Maria Cristina Breschi,Vincenzo Calderone +11 more
TL;DR: A significant reduction of the systolic blood pressure of anesthetized normotensive rats was observed after its oral administration and highlighted the potential of arylthioamides 1-3 and 7 as H2S-donors for basic studies, and for the rational design/development of promising pharmacotherapeutic agents to treat cardiovascular diseases.
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(+/−)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells
Simona Saponara,Lara Testai,D Iozzi,Enrica Martinotti,Alma Martelli,Silvio Chericoni,Giampietro Sgaragli,Fabio Fusi,Vincenzo Calderone +8 more
TL;DR: The aim of this study was to investigate, in vascular smooth muscle cells, the mechanical and electrophysiological effects of (+/−)‐naringenin.
Journal ArticleDOI
Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels.
Alma Martelli,Lara Testai,Maria Cristina Breschi,Kim Lawson,Nc Mckay,Francesco Miceli,Maurizio Taglialatela,Maurizio Taglialatela,Vincenzo Calderone +8 more
TL;DR: Results suggest that the activation of Kv7.4 channels is a key mechanism in the vascular effects of H2S, and should be focused on as novel targets for therapeutic approaches via the "H2S-system".
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Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels.
Lorenzo Di Cesare Mannelli,Elena Lucarini,Laura Micheli,Ilaria Mosca,Paolo Ambrosino,Maria Virginia Soldovieri,Alma Martelli,Lara Testai,Maurizio Taglialatela,Vincenzo Calderone,Carla Ghelardini +10 more
TL;DR: The aim of the present study was to investigate the pain relieving profile of a series of slow releasing H2S donors in animal models of neuropathic pain induced by paclitaxel or oxaliplatin, anticancer drugs characterized by a dose-limiting neurotoxicity.