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Alonso Barrantes-Freer
Researcher at University of Göttingen
Publications - 30
Citations - 1080
Alonso Barrantes-Freer is an academic researcher from University of Göttingen. The author has contributed to research in topics: Multiple sclerosis & Brain metastasis. The author has an hindex of 17, co-authored 27 publications receiving 683 citations. Previous affiliations of Alonso Barrantes-Freer include Leipzig University & Max Planck Society.
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Journal ArticleDOI
Myelin in the Central Nervous System: Structure, Function, and Pathology.
TL;DR: The biology of myelin, the expanded relationship of myelinating oligodendrocytes with its underlying axons and the neighboring cells, and its disturbances in various diseases such as multiple sclerosis, acute disseminated encephalomyelitis, and neuromyELitis optica spectrum disorders are reviewed.
Journal ArticleDOI
Frequency of BRAF V600E mutations in 969 central nervous system neoplasms.
Felix Behling,Alonso Barrantes-Freer,Marco Skardelly,Maike Nieser,Arne Christians,Florian Stockhammer,Veit Rohde,Marcos Tatagiba,Christian Hartmann,Christine Stadelmann,Jens Schittenhelm +10 more
TL;DR: Routine screening for BRAF V600E mutations for glioblastomas WHO grade IV below the age of 30 is suggested, especially in gliOBlastomas with epithelioid features and in all rhabdoid meningiomasWHO grade III.
Journal ArticleDOI
The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study
Laila Siam,Annalen Bleckmann,Han-Ning Chaung,Alexander Mohr,Florian Klemm,Alonso Barrantes-Freer,Raquel Blazquez,Hendrik A. Wolff,Florian Lüke,Veit Rohde,Christine Stadelmann,Tobias Pukrop,Tobias Pukrop +12 more
TL;DR: The astrocyte reaction at the M/BP-interface is heterogeneous and supports the previous concept of the organ-specific defense against metastatic (organ-foreign) cells in brain metastases resection, and has a significant impact on prognosis.
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Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation
Hila Schwartz,Eran Blacher,Malak Amer,Nir Livneh,Lilach Abramovitz,Anat Klein,Dikla Ben-Shushan,Shelly Soffer,Raquel Blazquez,Alonso Barrantes-Freer,Meike Müller,Karin Müller-Decker,Reuven Stein,Galia Tsarfaty,Ronit Satchi-Fainaro,Viktor Umansky,Tobias Pukrop,Neta Erez +17 more
TL;DR: It is demonstrated that micrometastases are associated with instigation of astrogliosis, neuroinflammation, and hyperpermeability of the blood-brain barrier, and a functional role for astrocytes is shown in facilitating initial growth of melanoma cells.
Journal ArticleDOI
Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor
Éva Lörinczi,Yogesh Bhargava,Stephen F. Marino,Antoine Taly,Karina Kaczmarek-Hajek,Alonso Barrantes-Freer,Sébastien Dutertre,Thomas Grutter,Jürgen Rettinger,Annette Nicke +9 more
TL;DR: Voltage clamp fluorometry data confirm the proposed ATP binding site and provide evidence that ATP orients in its binding site with the ribose moiety facing the solution, and conclude that P2XR activation and desensitization involve movements of the cysteine-rich head domain.