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Amarbirpal Mahal
Researcher at Guy's Hospital
Publications - 18
Citations - 5461
Amarbirpal Mahal is an academic researcher from Guy's Hospital. The author has contributed to research in topics: Huntington's disease & Neurodegeneration. The author has an hindex of 18, co-authored 18 publications receiving 5273 citations. Previous affiliations of Amarbirpal Mahal include King's College London & University College London.
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Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.
Rebecca J. Carter,Lisa Lione,Trevor Humby,Laura Mangiarini,Amarbirpal Mahal,Gillian P. Bates,Stephen B. Dunnett,A.J. Morton +7 more
TL;DR: R6/2 mice show measurable deficits in motor behavior that begin subtly and increase progressively until death and indicate that they may be useful for evaluating therapeutic strategies for HD, particularly those aimed at reducing the severity of motor symptoms or slowing the course of the disease.
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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
Emma Hockly,Victoria M. Richon,Benjamin Woodman,Donna L. Smith,Xianbo Zhou,E. Rosa,Kirupa Sathasivam,Shabnam Ghazi-Noori,Amarbirpal Mahal,Philip A. S. Lowden,Joan S. Steffan,J.L. Marsh,Leslie M. Thompson,Cathryn M. Lewis,Paul A. Marks,Gillian P. Bates +15 more
TL;DR: Preclinical trials with suberoylanilide hydroxamic acid (SAHA), a potent HDAC inhibitor, show that SAHA crosses the blood–brain barrier and increases histone acetylation in the brain, clearly validating the pursuit of this class of compounds as HD therapeutics.
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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease
Mark Turmaine,Aysha S. Raza,Amarbirpal Mahal,Laura Mangiarini,Gillian P. Bates,Stephen W. Davies +5 more
TL;DR: It is suggested that the mechanism of neuronal cell death in both HD and a transgenic mouse model of HD is neither by apoptosis nor by necrosis.
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Abnormal Synaptic Plasticity and Impaired Spatial Cognition in Mice Transgenic for Exon 1 of the Human Huntington's Disease Mutation
Kerry P.S.J. Murphy,Rebecca J. Carter,Lisa Lione,Laura Mangiarini,Amarbirpal Mahal,Gillian P. Bates,Stephen B. Dunnett,A. Jennifer Morton +7 more
TL;DR: The temporal and regional changes in synaptic plasticity within the hippocampus mirror the appearance of neuronal intranuclear inclusions, suggesting a relationship between polyglutamine aggregation and dysfunction.
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Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.
Sarah J. Tabrizi,J Workman,Paul E. Hart,L Mangiarini,Amarbirpal Mahal,Gillian P. Bates,JM Cooper,Anthony H.V. Schapira +7 more
TL;DR: A transgenic mouse model (R6/2) of Huntington's disease developed a movement disorder, muscle wasting, and premature death at about 14 to 16 weeks, with selective neuronal death in these mice is not seen until 14 weeks.