J
JM Cooper
Researcher at Royal Free Hospital
Publications - 76
Citations - 14192
JM Cooper is an academic researcher from Royal Free Hospital. The author has contributed to research in topics: Mitochondrion & Respiratory chain. The author has an hindex of 42, co-authored 75 publications receiving 13687 citations.
Papers
More filters
Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
TL;DR: Results indicated a specific defect of Complex I activity in the substantia nigra of patients with Parkinson's disease, which adds further support to the proposition that Parkinson’s disease may be due to an environmental toxin with action(s) similar to those of MPTP.
Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
Journal ArticleDOI
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases.
M. W. J. Cleeter,JM Cooper,Victor M. Darley-Usmar,Salvador Moncada,Anthony H.V. Schapira,Anthony H.V. Schapira +5 more
TL;DR: Results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of Nitric oxide in the CNS and other tissues.
Journal ArticleDOI
Mitochondrial defect in Huntington's disease caudate nucleus
TL;DR: The mitochondrial defect identified in HD caudate parallels that induced by HD neurotoxin models and further supports the role of abnormal energy metabolism in HD.
Journal ArticleDOI
Anatomic and Disease Specificity of NADH CoQ1 Reductase (Complex I) Deficiency in Parkinson's Disease
Anthony H.V. Schapira,V. M. Mann,JM Cooper,D. Dexter,S. E. Daniel,Peter Jenner,J. B. Clark,C. D. Marsden +7 more
TL;DR: It is shown that complex I deficiency in Parkinson's disease is anatomically specific for the substantia nigra, and is not present in another neurodegenerative disorder involving the substanta nigra.