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Aminah Wali
Researcher at University of North Carolina at Chapel Hill
Publications - 4
Citations - 779
Aminah Wali is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Butyrate & Chromatin. The author has an hindex of 3, co-authored 3 publications receiving 608 citations.
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Journal ArticleDOI
The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
TL;DR: It is demonstrated that metabolic transformation plays an important role in the development of cancer cells and that butyrate stimulated the proliferation of normal colonocytes and cancerous colonocytes when the Warburg effect was prevented from occurring.
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Microbial Regulation of Glucose Metabolism and Cell-Cycle Progression in Mammalian Colonocytes
TL;DR: The experiments demonstrated that microbiota are required for energy homeostasis in the proximal colon to a greater extent than other segments of the GI tract that also harbor high densities of bacteria, and revealed a mechanism by which microbiota regulate glucose utilization to influence energyHomeostasis and cell-cycle progression of mammalian host cells.
Journal ArticleDOI
High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility
Samantha G. Pattenden,Jeremy M. Simon,Aminah Wali,Chatura N. Jayakody,Jacob Troutman,Andrew W. McFadden,Joshua Wooten,Cameron Champion Wood,Stephen V. Frye,William P. Janzen,Ian J. Davis +10 more
TL;DR: It is demonstrated that the Ewing sarcoma chimeric transcription factor, EWSR1-FLI1, maintains accessible chromatin at disease-specific regions and is identified as a specific class of compounds with therapeutic potential.
Journal ArticleDOI
MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing
T. S. Vital,Aminah Wali,Kyle V. Butler,Yan Xiong,Joseph P. Foster,S. Marcel,Andrew W. McFadden,Valerie Nguyen,B. M. Bailey,Kelsey N. Lamb,Lindsey I. James,Stephen V. Frye,Amber L. Mosely,Jian Jin,Samantha G. Pattenden,Ian J. Davis +15 more
TL;DR: In this paper , a small molecule called MS0621 was identified as a modulator of chromatin state at sites of aberrant chromatin accessibility at EWSR1::FLI1-bound loci.