Rebecca L. Bigler

TL;DR: It is demonstrated that metabolic transformation plays an important role in the development of cancer cells and that butyrate stimulated the proliferation of normal colonocytes and cancerous colonocytes when the Warburg effect was prevented from occurring.

TL;DR: In this article, the authors identify a cytosine-recognition code by screening random amino acid combinations at conserved RNA recognition positions using a yeast three-hybrid system, which can be applied to design PUF domains that recognize targets with multiple cytosines and generate engineered splicing factors that modulate alternative splicing.

TL;DR: Knockdown of the exosome-associated exonuclease PM/Scl-100, but not the Dis3L2 ex onuclease, slows histone mRNA degradation consistent with 3' to 5' degradation by theExosome containing PM/ Scl- 100, suggesting a role in removing ribosomes from partially degraded mRNAs.

TL;DR: The novel finding that oxytocin mRNA localized to these human projections and confirmed its localization using RNA-FISH is reported, providing an important resource for studying local mRNA translation and has the potential to reveal both conserved and unique translation dependent mechanisms.

TL;DR: How severed distal axons signal back to the cell body to induce hyperexcitability, loss of inhibition and enhanced presynaptic release through netrin-1 is studied.