Amir Foroushani

TL;DR: The recent integration of bovine data makes InnateDB the first integrated network analysis platform for this agriculturally important model organism, and a range of improvements to the integrated bioinformatics solutions are reported.

TL;DR: A next generation sequencing approach profiling the expression of miRNAs in primary bovine mammary epithelial cells at 1, 2, 4 and 6 hours post-infection with Streptococcus uberis suggests that mi RNAs, which potentially act as central regulators of gene expression responses to a Gram-positive bacterial infection, may significantly regulate the sentinel capacity of mammaries to mobilise the innate immune system.

TL;DR: Curation of the InnateDB interactome provides a wealth of information to enable systems-level analysis of innate immunity and provides several lines of evidence that analysis of the innate immunity interactome has the potential to identify novel signalling, transcriptional and post-transcriptional regulators of innate Immunity.

TL;DR: Observations indicate that Lin28b–Igf2bp3 are developmental regulators that mediate the fetal–adult hematopoietic switch.

TL;DR: A novel method based on the analyses of coexpression networks and Bayesian networks is introduced, and this new method is used to classify two types of hematological malignancies; namely, acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).