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Anastasia Sribnaia
Researcher at European Bioinformatics Institute
Publications - 5
Citations - 1206
Anastasia Sribnaia is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Gut flora & Innate immune system. The author has an hindex of 4, co-authored 5 publications receiving 913 citations. Previous affiliations of Anastasia Sribnaia include University of British Columbia.
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Journal ArticleDOI
InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation
Karin Breuer,Amir Foroushani,Matthew R. Laird,Carol Chen,Anastasia Sribnaia,Raymond Lo,Geoffrey L. Winsor,Robert E. W. Hancock,Fiona S. L. Brinkman,David J. Lynn +9 more
TL;DR: The recent integration of bovine data makes InnateDB the first integrated network analysis platform for this agriculturally important model organism, and a range of improvements to the integrated bioinformatics solutions are reported.
Journal ArticleDOI
Early-Life Antibiotic-Driven Dysbiosis Leads to Dysregulated Vaccine Immune Responses in Mice
Miriam A. Lynn,Damon J. Tumes,Jocelyn M. Choo,Anastasia Sribnaia,Stephen J. Blake,Lex E. X. Leong,Graeme P. Young,Helen Marshall,Steve Lodewijk Wesselingh,Geraint B. Rogers,David J. Lynn +10 more
TL;DR: It is demonstrated that, in mice, antibiotic-driven dysregulation of the gut microbiota in early life can modulate immune responses to vaccines that are routinely administered to infants worldwide.
Journal ArticleDOI
Curating the innate immunity interactome
David J. Lynn,Calvin Chan,Misbah Naseer,Melissa Yau,Raymond Lo,Anastasia Sribnaia,Giselle Ring,Jaimmie Que,Kathleen Wee,Geoffrey L. Winsor,Matthew R. Laird,Karin Breuer,Amir Foroushani,Amir Foroushani,Fiona S. L. Brinkman,Robert E. W. Hancock +15 more
TL;DR: Curation of the InnateDB interactome provides a wealth of information to enable systems-level analysis of innate immunity and provides several lines of evidence that analysis of the innate immunity interactome has the potential to identify novel signalling, transcriptional and post-transcriptional regulators of innate Immunity.
Journal ArticleDOI
The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life
Miriam A. Lynn,Georgina Eden,Feargal J. Ryan,Julien Bensalem,Xuemin Wang,Stephen J. Blake,Jocelyn M. Choo,Yee Tee Chern,Anastasia Sribnaia,Jane James,Saoirse C. Benson,Lauren Y. Sandeman,Jianling Xie,Sofia Hassiotis,Emily W. Sun,Alyce M. Martin,Marianne D. Keller,Damien J. Keating,Timothy J. Sargeant,Christopher G. Proud,Steven Lodewyk Wesselingh,Geraint B. Rogers,David J. Lynn +22 more
TL;DR: It is suggested that differences in the composition of the gut microbiota following antibiotic exposure differentially affect host health and longevity in later life.
Journal ArticleDOI
Changes in the Composition of the Gut Microbiota and the Blood Transcriptome in Preterm Infants at Less than 29 Weeks Gestation Diagnosed with Bronchopulmonary Dysplasia.
Feargal J. Ryan,Damian P. Drew,Chloe Douglas,Lex E. X. Leong,Max Moldovan,Miriam A. Lynn,Naomi H. Fink,Anastasia Sribnaia,Irmeli A. Penttila,Andrew J McPhee,Carmel T Collins,Maria Makrides,Robert A. Gibson,Geraint B. Rogers,David J. Lynn +14 more
TL;DR: There are significant differences in the gut microbiota of infants born at <29 weeks gestation and subsequently diagnosed with BPD, which are particularly pronounced when infants are stratified by birth mode, and an association between the composition of the microbiota and immune gene expression in blood in early life is identified.