Showing papers by "Amit Anand published in 2014"
TL;DR: This review article focuses on the recent developments (2010-2014) on various pharmacological and medicinal aspects of chalcones and their analogues.
521 citations
TL;DR: PIWI proteins Hywi and Hyli in the cnidarian Hydra are investigated, and it is found that both PIWI proteins are enriched in multipotent stem cells, germlinestem cells, and in the female germline.
67 citations
TL;DR: The observations suggest that tej and tap work together for germline maintenance, and also function in a synergistic manner to maintain examined piRNA components at the perinuclear nuage and for piRNA production in Drosophila germline cells.
Abstract: Background
Piwi-interacting RNAs (piRNAs) are a special class of small RNAs that provide defense against transposable elements in animal germline cells. In Drosophila, germline piRNAs are thought to be processed at a unique perinuclear structure, the nuage, that houses piRNA pathway proteins including the Piwi clade of Argonaute family proteins, along with several Tudor domain proteins, RNA helicases and nucleases. We previously demonstrated that Tudor domain protein Tejas (Tej), an ortholog of vertebrate Tdrd5, is an important component of the piRNA pathway.
47 citations
TL;DR: A facile, single pot diastereoselective access to seven and eight membered aza-heterocycles was developed by using β-lactam-synthon approach.
6 citations
TL;DR: The key issue is whether the localization of piRNA pathway proteins to the nuage is compromised in absence of qin, and the two groups used different alleles and Zhang et al challenge some of the findings.
Abstract: Two recent reports by Zhang et al published in Nov (2011) and our group (Anand & Kai, 2012; published online in Dec 2011) have suggested a role for the conserved Tudor domain protein encoded by qin as a component of piRNA pathway. Both studies agree that qin plays a role in the piRNA pathway and is required to repress reteroelements but differ in some aspects of their conclusions about qin function. We reported that kumo M41‐13 , hereafter designated qin kumo , homozygous females exhibited mislocalization of many piRNA pathway components from the nuage, a perinuclear structure where piRNA pathway components are concentrated in the ovary. We also reported a reduction in piRNAs targeting transposons (Supplementary Table 3 in Anand & Kai, 2012). In contrast, Zhang et al found no change in localization of piRNA pathway components to the nuage and observed an increase in Aubergine(Aub)‐Aub homotypic ping‐pong in the qin 1 /Df alleleic combination, which led Zhang et al to propose that qin is required for maintenance of heterotypic, Aub‐Argonaute3 (Ago3) ping‐pong (Zhang et al , 2011).
In the accompanying Correspondence, Zhang et al challenge some of our findings. The key issue is whether the localization of piRNA pathway proteins to the nuage is compromised in absence of qin . The two groups used different alleles …
4 citations
TL;DR: A review article as mentioned in this paper focuses on the recent developments (2010-2014) on various pharmacological and medicinal aspects of chalcones and their analogues and their effect on the development of more potent and efficient drugs for the treatment of several dreadful diseases.
Abstract: Chalcones represent key structural motif in the plethora of biologically active molecules including synthetic and natural products. Synthetic manipulations of chalcones or their isolation from natural sources are being investigated worldwide for the development of more potent and efficient drugs for the treatment of several dreadful diseases such as cancer, diabetes, HIV, tuberculosis, malaria etc. Over the past few years, a large volume of research papers and review articles highlighting the significance of chalcone derivatives has been compiled in the literature. The present review article focuses on the recent developments (2010-2014) on various pharmacological and medicinal aspects of chalcones and their analogues.
2 citations