Showing papers in "Tetrahedron Letters in 2014"

TL;DR: Copper-catalyzed difunctionalization of unactivated carbon carbon multiple bonds involving a carbon carbon bond formation process is reviewed in this article, where carboamination, carbooxygenation, carboboration, and other dif-unctionalisation reactions of alkenes, alkynes, and allenes are described.

TL;DR: In this paper, the authors mainly discussed the recent typical examples in sp2 and sp3 C-H bond functionalization by means of visible-light photoredox catalysis, which is of considerable interest to academic and industrial chemists owing to the atom/step economical features as well as the overall sustainability.

TL;DR: In this article, the recent progresses in the synthesis and further derivations of diynes are discussed, as well as the precursors of basic heterocycles, which represented an emerging research area.

TL;DR: In this paper, the authors summarize the annulation reactions via chelation-assisted C−H activation leading to isoquinolines, isoquinolinium salts, or isoquinoline N-oxides.

TL;DR: In this article, an environmentally benign protocol for the synthesis of quinazolinones from anthranilamides and aldehydes via aerobic oxidation was developed in wet DMSO.

TL;DR: In this paper, transition-metal-mediated trifluoromethylation for the construction of various CF3-containing building blocks has been the focus of recent research in both industrial and academic communities.

TL;DR: In this paper, the authors summarized various copper-mediated cyanations based on the different kinds of cyanide reagents, such as metal cyanides, metal hexacyanoferrate(II), acetone cyanohydrins, DDQ, AIBN, benzyl cyanide, malononitrile, nitromethane, and DMF.

TL;DR: A number of transition metal catalysts have been developed for transfer hydrogenation of organic molecules as mentioned in this paper, which provides a useful process for the reduction of unsaturated molecules without the need for explosive hydrogen gas.

TL;DR: The catalytic asymmetric synthesis of 3,3-disubstituted oxindoles, a big family of privileged scaffolds in natural products and drugs, is of current interest.

TL;DR: In the past 20 years, organic chemists have made significant contributions to the development of transitionmetal-catalyzed ketone-directed ortho-C-H functionalization reactions as mentioned in this paper.

TL;DR: In this article, the metal-free catalytic asymmetric hydrogenation and hydrosilylation using frustrated Lewis pairs (FLP) catalysts has been discussed, and the authors outline the recent important progress.

TL;DR: In this article, tricyclic fused pyrazolopyranopyrimidines containing both biologically active pyranopyrazole and pyrnopyrimidine templates are synthesized using a one-pot, four-component reaction involving ethyl acetoacetate, hydrazine hydrate, benzaldehydes, and barbituric acid catalyzed by DABCO in water.

TL;DR: Asymmetric hydrogenation of ketones (AHK) was revolutionized in 1987 and again in 1995 when Ru(CH 3 COO) 2 (binap)/HCl and RuCl 2 (inap)/diamine, respectively, were developed as mentioned in this paper.

TL;DR: This digest review aims to give a brief overview of catalytic asymmetric α-C(sp3)–H functionalization of amines, mainly via internal tert-aminocyclization, intermolecular C–H oxidative couplings, and redox neutral metal insertion C-H bond.

TL;DR: New organocatalytic approaches are expected for the facile construction of polysubstituted pyrrolidines with well-controlled stereochemistry and for the practical synthesis of pyrrollidine-related natural alkaloids, drug candidates and functional proline derivatives.

TL;DR: In this paper, an AgNO3/K2S2O8 catalyzed one-pot radical route to β-keto sulfones from alkenes is reported, which allows the use of easily available starting materials in an open flask and aqueous medium at ambient temperature.

TL;DR: In this article, a coumarin-based sensor containing trifluoroacetyl acetonate moiety was designed, synthesized, and applied for hydrazine detection.

TL;DR: Significant progress has been made in the use of λ3- and λ5-iodanes in asymmetric dearomatization reactions and some of deficiencies in the literature that the author believes may be hindering further progress are revealed.

TL;DR: A review of the recent methods for C C bond formation via direct β-C H functionalization of carbonyl compounds can be found in this article, where the scope and limitation of each strategy are also discussed.

TL;DR: A visible light-induced photocatalytic aerobic oxidation/semipinacol rearrangement has been successfully developed and allows for efficient conversion of a wide range of indoles into the synthetically significant 2,2-disubstituted indolin-3-ones, the core structure of pseudoindoxyl alkaloids.

TL;DR: In this paper, an efficient one-pot, convenient catalysis for the synthesis of 5-substituted-1H-tetrazoles is reported, where the reaction proceeds via in situ formation of a silver azide species, which participates in coordination of nitrile moiety followed by cycloaddition of azide ion to give tetrazole.

TL;DR: In this paper, a facile synthetic protocol for the synthesis of 2-aryl-1,3-benzothiazoles and 1,3 -benzoxazoles has been demonstrated using ZnO nanoparticles as a mild and efficient heterogeneous catalyst.

TL;DR: A brief summary of recent disclosures in transition metal-catalyzed fluorination reactions at sp 3 -hybridized carbon centers with nucleophilic fluoride sources can be found in this article.

TL;DR: A series of benzofuran-2-carboxamides of biological and medicinal significance were synthesized by a microwave-assisted one-pot parallel approach via O-alkylation/Knoevenagel condensation as mentioned in this paper.

TL;DR: In this paper, the resonance-assisted H-bond (RAHB) in absolute water was used to detect cysteine/homocysteine in water as well as in live cells.

TL;DR: In this article, a 2,2-disulfediyl bis-( N -anthracen-9-ylmethylene)ethanamine (Cysan) based on anthracene platform was synthesized.

TL;DR: In this paper, the catalytic ability of Fe3O4@chitosan was described as an environmentally benign and stable composite nanocatalyst for the synthesis of benzodiazepine derivatives starting from o-phenylenediamine, dimedone, and different aldehydes via a one-pot, three-component reaction at room temperature.

TL;DR: The aza-oxyallylic cation is a reactive intermediate that undergoes a [4+3] cycloaddition with dienes to form seven-membered heterocycles as discussed by the authors.

TL;DR: In this article, a new Schiff base was synthesized, which detects Al 3+ through fluorescence and naked eye in aqueous solution, and the detection limit was 1.00μm, which is below the WHO acceptable limit (1.85μm) in drinking water.