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Amom Ruhikanta Meetei
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 22
Citations - 1785
Amom Ruhikanta Meetei is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: DNA repair & FANCM. The author has an hindex of 16, co-authored 22 publications receiving 1652 citations. Previous affiliations of Amom Ruhikanta Meetei include University of Cincinnati Academic Health Center.
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A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.
Amom Ruhikanta Meetei,Annette L. Medhurst,Chen Ling,Yutong Xue,Thiyam Ramsing Singh,Patrick Bier,Jurgen Steltenpool,Stacie Stone,Inderjeet Dokal,Christopher G. Mathew,Maureen E. Hoatlin,Hans Joenje,Johan P. de Winter,Weidong Wang +13 more
TL;DR: FAAP250 or FANCM has sequence similarity to known DNA-repair proteins, including archaeal Hef, yeast MPH1 and human ERCC4 or XPF and may act as an engine that translocates the Fanconi anemia core complex along DNA.
Journal ArticleDOI
Identification of FAAP24, a Fanconi Anemia Core Complex Protein that Interacts with FANCM
Alberto Ciccia,Chen Ling,Rachel Coulthard,Zhijiang Yan,Yutong Xue,Amom Ruhikanta Meetei,El Houari Laghmani,Hans Joenje,Neil Q. McDonald,Johan P. de Winter,Weidong Wang,Stephen C. West +11 more
TL;DR: The data indicate that the FANCM/FAAP24 complex may play a key role in recruitment of the FA core complex to damaged DNA.
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MHF1-MHF2, a Histone-Fold-Containing Protein Complex, Participates in the Fanconi Anemia Pathway via FANCM
Thiyam Ramsing Singh,Dorina Saro,Abdullah Mahmood Ali,Xiaofeng Zheng,Chang hu Du,Michael W. Killen,Aristidis Sachpatzidis,Kebola Wahengbam,Andrew J. Pierce,Yong Xiong,Patrick Sung,Amom Ruhikanta Meetei +11 more
TL;DR: It is shown that suppression of MHF1 expression results in destabilization of FANCM and MHF2, impairment of DNA damage-induced monoubiquitination and foci formation of FANCD2, and defective chromatin localization of FA nuclear core complex proteins.
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Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M
Thiyam Ramsing Singh,Sietske T. Bakker,Sietske T. Bakker,Sheba Agarwal,Michael Jansen,Elke Grassman,Barbara C. Godthelp,Abdullah Mahmood Ali,Chang-hu Du,Martin A. Rooimans,Qiang Fan,Kebola Wahengbam,Jurgen Steltenpool,Paul R. Andreassen,David A. Williams,Hans Joenje,Johan P. de Winter,Amom Ruhikanta Meetei +17 more
TL;DR: FANCM functions in an FA core complex-dependent and -independent manner, and a C-terminal deletion mutant rescued the cross-linker sensitivity of FancM(-/-) cells, whereas a FANCM ATPase mutant did not.
Journal ArticleDOI
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair
Jung-Young Park,Thiyam Ramsing Singh,Nicolas Nassar,Fan Zhang,Marcel Freund,Helmut Hanenberg,Amom Ruhikanta Meetei,Paul R. Andreassen +7 more
TL;DR: In this paper, the effects of missense mutants of the PALB2 WD40 domain that have been reported in breast cancer patients have been characterized, and the results suggest that three different cancer susceptibility and Fanconi anemia (FA) proteins function in a DNA repair pathway.