A
Amruta Manke
Researcher at Research Triangle Park
Publications - 15
Citations - 1467
Amruta Manke is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Cancer & Pulmonary fibrosis. The author has an hindex of 8, co-authored 15 publications receiving 1192 citations. Previous affiliations of Amruta Manke include RTI International & West Virginia University.
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Journal ArticleDOI
Mechanisms of nanoparticle-induced oxidative stress and toxicity.
TL;DR: Through physicochemical characterization and understanding of the multiple signaling cascades activated by NP-induced ROS, a systemic toxicity screen with oxidative stress as a predictive model for NP- induced injury can be developed.
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SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma
Sudjit Luanpitpong,Jingting Li,Amruta Manke,Kathleen M. Brundage,Emily Ellis,Sarah L. McLaughlin,Paweorn Angsutararux,Nawin Chanthra,Maria A. Voronkova,Yi Charlie Chen,Liying Wang,Pithi Chanvorachote,Ming Pei,Surapol Issaragrisil,Yon Rojanasakul +14 more
TL;DR: A novel mechanistic insight is provided into the regulation of CSCs via SLUG-SOX9 regulatory axis, which represents a potential novel target for CSC therapy that may overcome cancer chemoresistance and relapse.
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Effect of fiber length on carbon nanotube-induced fibrogenesis:
Amruta Manke,Sudjit Luanpitpong,Chenbo Dong,Liying Wang,Xiaoqing He,Lori A. Battelli,Raymond C. Derk,Todd A. Stueckle,Dale W. Porter,Tina M. Sager,Honglei Gou,Cerasela Zoica Dinu,Nianqiang Wu,Robert R. Mercer,Yon Rojanasakul +14 more
TL;DR: This study provides new evidence for the role of fiber length in SWCNT-induced lung fibrosis and offers a rapid cell-based assay for fibrogenicity testing of nanomaterials with the ability to predict pulmonary fibrogenic response in vivo.
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Pulmonary toxicity and fibrogenic response of carbon nanotubes
TL;DR: This review discusses major cellular and molecular events governing pulmonary fibrosis, the physicochemical properties of CNTs and their effects on pulmonary toxicities as well as various biological factors contributing to the development of fibrosis.
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Potential in vitro model for testing the effect of exposure to nanoparticles on the lung alveolar epithelial barrier.
TL;DR: This work demonstrates a well-characterized in vitro model of pulmonary barrier function using Calu-3 cells, and provides the experimental conditions required for achieving tight junction complexes in cell culture, with trans-epithelial electrical resistance measurement used as a biosensor for proper barrier formation and integrity.