Amy Estes

TL;DR: The histopathological features of different layers of cornea and the differentially expressed proteins in the KC-affected cornea are summarized and discussed to help emphasize the major molecular defects in KC and identify additional research areas related to KC.

TL;DR: This study highlighted the potential roles of several genes (CTGF, SFRP1, AQP5, lnc-WNT4-2-2:1, and lNC-ALDH3A2- 2:1) and pathways (TGF-β, WNT signaling, and PI3K/AKT pathways) in KC pathogenesis.

TL;DR: Using in vitro cellular model and in vivo gene-trap mouse model, critical evidence is found to support the role of PPIP5K2 in normal corneal function and KC pathogenesis and for the first time,Corneal tomography and pachymetry mapping are integrated into characterization of mouse cornea phenotypes which could be widely implemented in basic and translational research for KC diagnosis and therapy.

TL;DR: The results indicate the importance of the AQP3/PLD2/PG signaling pathway in corneal epithelial cells and suggest the possibility of developing DOPG as a pharmacologic therapy to enhanceCorneal wound healing in patients.

TL;DR: A method of in-strip protein digestion that identified >3000 proteins in human tear samples from 11 healthy subjects is established, which offers a significant improvement in the number of proteins identified compared to previously reported methods without pooling samples.