Amy J. Pawlik

TL;DR: A strategy for whole-body rehabilitation-consisting of interruption of sedation and physical and occupational therapy in the earliest days of critical illness-was safe and well tolerated, and resulted in better functional outcomes at hospital discharge, a shorter duration of delirium, and more ventilator-free days compared with standard care.

TL;DR: Early physical and occupational therapy is feasible from the onset of mechanical ventilation despite high illness acuity and presence of life support devices, and adverse events related to this intervention are uncommon.

TL;DR: The guideline panel provided recommendations for inspiratory pressure augmentation during an initial SBT, protocols minimizing sedation, and preventative NIV, in relation to ventilator liberation.

TL;DR: This guideline, a collaborative effort between the American Thoracic Society and the American College of Chest Physicians, provides evidence‐based recommendations to optimize liberation from mechanical ventilation in critically ill adults.

TL;DR: This clinical practice guideline addresses six questions related to liberation from mechanical ventilation in critically ill adults using the Grading of Recommendations, Assessment, Development, and Evaluation approach.