Anne S. Pohlman

TL;DR: A randomized, controlled trial involving 128 adult patients who were receiving mechanical ventilation and continuous infusions of sedative drugs in a medical intensive care unit found that the intervention group increased the median duration of mechanical ventilation, as compared with 7.3 days in the control group.

TL;DR: A strategy for whole-body rehabilitation-consisting of interruption of sedation and physical and occupational therapy in the earliest days of critical illness-was safe and well tolerated, and resulted in better functional outcomes at hospital discharge, a shorter duration of delirium, and more ventilator-free days compared with standard care.

TL;DR: It is suggested that a wake up and breathe protocol that pairs daily spontaneous awakening trials (ie, interruption of sedatives) with daily spontaneous breathing trials results in better outcomes for mechanically ventilated patients in intensive care than current standard approaches and should become routine practice.

TL;DR: It is concluded that daily sedative interruption does not result in adverse psychological outcomes, reduces symptoms of PTSD, and may be associated with reductions in posttraumatic stress disorder.

TL;DR: Treatment with helmet NIV resulted in a significant reduction of intubation rates among patients with ARDS and a statistically significant reduction in 90-day mortality.