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Scott Stawicki
Researcher at Genentech
Publications - 44
Citations - 6010
Scott Stawicki is an academic researcher from Genentech. The author has contributed to research in topics: Epitope & Fibroblast growth factor receptor 1. The author has an hindex of 24, co-authored 43 publications receiving 5642 citations. Previous affiliations of Scott Stawicki include Hoffmann-La Roche.
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Journal ArticleDOI
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
John B. Ridgway,Gu Zhang,Yan Wu,Scott Stawicki,Wei-Ching Liang,Yvan Chanthery,Joe Kowalski,Ryan J. Watts,Christopher A. Callahan,Ian Kasman,Mallika Singh,May Chien,Christine Tan,Jo Anne Hongo,Fred de Sauvage,Greg Plowman,Minhong Yan +16 more
TL;DR: It is shown that Dll4-mediated Notch signalling has a unique role in regulating endothelial cell proliferation and differentiation, and is crucial during active vascularization, but less important for normal vessel maintenance.
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Therapeutic antibody targeting of individual Notch receptors
Yan Wu,Carol Cain-Hom,Lisa Choy,Thijs J. Hagenbeek,Gladys P. de Leon,Yongmei Chen,David Finkle,Rayna Venook,Xiumin Wu,John B. Ridgway,Dorreyah Schahin-Reed,Graham J. Dow,Amy L. Shelton,Scott Stawicki,Ryan J. Watts,Jeff Zhang,Robert Choy,Peter Howard,Lisa C. Kadyk,Minhong Yan,Jiping Zha,Christopher A. Callahan,Sarah G. Hymowitz,Christian W. Siebel +23 more
TL;DR: The studies emphasize the value of paralogue-specific antagonists in dissecting the contributions of distinct Notch receptors to differentiation and disease and reveal the therapeutic promise in targeting Notch1 and Notch2 independently.
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Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth
Qi Pan,Yvan Chanthery,Wei-Ching Liang,Scott Stawicki,Judy Mak,Nisha Rathore,Raymond K. Tong,Joe Kowalski,Sharon Yee,Glenn Pacheco,Sarajane Ross,Zhiyong Cheng,Jennifer Le Couter,Greg Plowman,Franklin Peale,Alexander W. Koch,Yan Wu,Anil Bagri,Marc Tessier-Lavigne,Ryan J. Watts +19 more
TL;DR: It is proposed that blocking NRP1 function inhibits vascular remodeling, rendering vessels more susceptible to anti-VEGF therapy, and generated two monoclonal antibodies that bind to the Sema- and VEGF-binding domains of N RP1.
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PirB Is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration
Jasvinder K. Atwal,Julie Pinkston-Gosse,Josh Syken,Scott Stawicki,Yan Wu,Carla J. Shatz,Carla J. Shatz,Marc Tessier-Lavigne +7 more
TL;DR: This work has found that paired immunoglobulin-like receptor B (PirB), which has been implicated in nervous system plasticity, is a high-affinity receptor for Nogo, MAG, and OMgp, and partially rescues neurite inhibition by Nogo66,MAG, OM gp, and myelin in cultured neurons.
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A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Gabriele Schaefer,Lauric Haber,Lisa Crocker,Steven Shia,Lily Shao,Donald Dowbenko,Klara Totpal,Anne Wong,Chingwei Vivian Lee,Scott Stawicki,Robyn Clark,Carter Fields,Gail Lewis Phillips,Rodney A. Prell,Dimitry M. Danilenko,Yvonne Franke,Jean-Philippe Stephan,Jiyoung Hwang,Yan Wu,Jenny Bostrom,Mark X. Sliwkowski,Germaine Fuh,Charles Eigenbrot +22 more
TL;DR: Compared with monospecific anti-HER antibodies, MEHD7945A was more broadly efficacious in multiple tumor models, showing that combined inhibition of EGFR and HER3 with a single antibody is beneficial.