Ana I. García-Pérez

TL;DR: Investigation of subcellular organelles using the pulse-field gradient spin-echo 1H NMR technique reveals important differences in molecular crowding within the different sub cellular compartments, suggesting considerable diffusional heterogeneity for small metabolites within theDifferent intracellular organells.

TL;DR: DQA-induced NB4 and K562 cell alterations are initiated within the first 30 min of treatment at a high DQA concentration with a mitochondrial membrane depolarization, and apoptosis by a typical caspase-9/caspase3-dependent intrinsic pathway is induced.

TL;DR: New knowledge is improved on DQA as a novel anticancer agent with a potential application in human acute promyelocytic leukemia chemotherapy and cell death seems to be mediated by alterations of mitochondrial function.

TL;DR: Data support a relevant differential role for NFkB and Nrf2 in anti-inflammatory and redox response when apoptosis was induced by esculetin or quercetin in human leukemia NB4 cells.

TL;DR: Dequalinium, a lipophilic drug with anti-cancer activity has been incorporated into mouse red blood cells and polyethylene glycol phosphatidylethanolamine micelles in order to overcome the drug's solubility problems and to make it suitable for in vivo applications.