M
M. Dolores Delgado
Researcher at Spanish National Research Council
Publications - 48
Citations - 2399
M. Dolores Delgado is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Myeloid leukemia & Cellular differentiation. The author has an hindex of 25, co-authored 48 publications receiving 2123 citations. Previous affiliations of M. Dolores Delgado include University Hospital of Lausanne & University of Alcalá.
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Journal ArticleDOI
Myc and cell cycle control.
TL;DR: The knowledge of the Myc-dependent cell cycle regulatory mechanisms will help to discover new therapeutic approaches directed against malignancies with deregulated Myc.
Journal ArticleDOI
Myc Roles in Hematopoiesis and Leukemia
M. Dolores Delgado,Javier León +1 more
TL;DR: The study of genetically modified mice with overexpression or deletion of Myc has shown that c-Myc is required for the correct balance between self-renewal and differentiation of hematopoietic stem cells (HSCs), and enforced expression of c- myc blocks the differentiation in several leukemia-derived cell lines capable of differentiating in culture.
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Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors
Stéphanie Renaud,Elena M. Pugacheva,M. Dolores Delgado,Richard Braunschweig,Ziedulla Abdullaev,Dmitri Loukinov,Jean Benhattar,Victor V. Lobanenkov +7 more
TL;DR: It is found that DNA methylation and functional p53 contributes to the negative regulation of each promoter and reduction of CTCF in normally BORis-negative human fibroblasts resulted in derepression of BORIS promoters.
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CTCF regulates the local epigenetic state of ribosomal DNA repeats
Suzanne van de Nobelen,Suzanne van de Nobelen,Manuel Rosa-Garrido,Joerg Leers,Helen Heath,Widia Soochit,Linda Joosen,Iris Jonkers,Jeroen Demmers,Michael I.J.A. van der Reijden,Verónica Torrano,Frank Grosveld,M. Dolores Delgado,Rainer Renkawitz,Niels Galjart,Frank Sleutels +15 more
TL;DR: UBF is the first common interaction partner of CTCF and CTCFL, suggesting a role for these proteins in chromatin organization of the rDNA repeats, similar to RNA polymerase II promoters.
Journal ArticleDOI
Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism.
Verónica Torrano,Joaquín Navascués,Ru Zhang,Les J. Burke,Igor Chernukhin,Dawn Farrar,Javier León,Maria T. Berciano,Rainer Renkawitz,Elena Klenova,Miguel Lafarga,M. Dolores Delgado +11 more
TL;DR: The data show that nucleolar localization of CTCF is associated with growth arrest and it is demonstrated that the central zinc-finger domain of C TCF is the region responsible for nucleolar targeting.