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Ana M. Gamo
Researcher at Complutense University of Madrid
Publications - 7
Citations - 306
Ana M. Gamo is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Innate immune system & Small molecule. The author has an hindex of 7, co-authored 7 publications receiving 147 citations. Previous affiliations of Ana M. Gamo include Spanish National Research Council & Torrey Pines Institute for Molecular Studies.
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Journal ArticleDOI
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic
Emily N. Chin,Chenguang Yu,Chenguang Yu,Vincent F. Vartabedian,Ying Jia,Manoj Kumar,Ana M. Gamo,William Vernier,Sabrina H. Ali,Mildred Kissai,Daniel C. Lazar,Nhan T. Nguyen,Laura E. Pereira,Brent Benish,Ashley K. Woods,Sean B. Joseph,Alan Chu,Kristen Johnson,Philipp N. Sander,Francisco Martínez-Peña,Eric Hampton,Travis S. Young,Dennis W. Wolan,Arnab K. Chatterjee,Peter G. Schultz,Peter G. Schultz,H. Michael Petrassi,John R. Teijaro,Luke L. Lairson +28 more
TL;DR: A non-nucleotide, small-molecule STING agonist, termed SR-717, that demonstrates broad interspecies and interallelic specificity and functions as a direct cyclic guanosine monophosphate–adenosine monophile mimetic that induces the same “closed” conformation of STING.
Journal ArticleDOI
Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.
Mario de la Fuente Revenga,Concepción Pérez,José A. Morales-García,Sandra Alonso-Gil,Ana Perez-Castillo,Daniel-Henri Caignard,Matilde Yáñez,Ana M. Gamo,María Isabel Rodríguez-Franco +8 more
TL;DR: Melatonin rigid analogues resulting from the hybridization of both pinoline and melatonin structures were able to stimulate early neurogenesis and neuronal maturation in an in vitro model of neural stem cells isolated from the adult rat subventricular zone.
Journal ArticleDOI
Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes
Federico Camicia,Ana M. Celentano,Malcolm E. Johns,John D. Chan,Lucas Luciano Maldonado,Hugo R. Vaca,Nicolás Di Siervi,Laura Kamentezky,Ana M. Gamo,Silvia Ortega-Gutiérrez,Mar Martín-Fontecha,Carlos Davio,Jonathan S. Marchant,Mara Cecilia Rosenzvit +13 more
TL;DR: These data provide the first functional report of GPCRs in parasitic cestodes and may represent novel druggable targets for antiparasitic intervention.
Journal ArticleDOI
Development of Fluorescent Ligands for the Human 5-HT1A Receptor
Dulce Alonso,Henar Vázquez-Villa,Ana M. Gamo,María F. Martínez-Esperón,Mariola Tortosa,Alma Viso,Roberto Fernández de la Pradilla,Elena Junquera,Emilio Aicart,Mar Martín-Fontecha,Bellinda Benhamú,María L. López-Rodríguez,Silvia Ortega-Gutiérrez +12 more
TL;DR: The design and synthesis of a set of fluorescent probes targeting the human 5-HT1A receptor (h5- HT1AR) and derivative 4 deserves special attention as being a high-affinity ligand with good fluorescent properties, which represents the first efficacious fluorescent probe for the specific labeling of h5-HT 1AR in cells.
Journal ArticleDOI
Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase.
Alejandro Revuelto,Marta Ruiz-Santaquiteria,Héctor de Lucio,Ana M. Gamo,Alejandra A. Carriles,Kilian Jesús Gutierrez,Pedro A. Sánchez-Murcia,Juan A. Hermoso,Federico Gago,María-José Camarasa,Antonio Jiménez-Ruiz,Sonsoles Velázquez +11 more
TL;DR: The pyrrolopyrimidine and the 5-6-5 imidazole-phenyl-thiazole α-helix-mimetic scaffolds were suitably decorated with substituents that could mimic three key residues (K, Q, and I) of the linear peptide prototype (PKIIQSVGIS-nle-K-Nle).