Francisco Martínez-Peña

TL;DR: A non-nucleotide, small-molecule STING agonist, termed SR-717, that demonstrates broad interspecies and interallelic specificity and functions as a direct cyclic guanosine monophosphate–adenosine monophile mimetic that induces the same “closed” conformation of STING.

TL;DR: It is identified that HSP90 inhibitors robustly decrease PD-L1 surface expression, through a mechanism that appears to involve the regulation of master transcriptional regulators (i.e., STAT-3 and c-Myc).

TL;DR: A sequential model optimization search utilising a deep learning model is employed to quickly discover synergistic drug combinations active against a cancer cell line, requiring substantially less screening than an exhaustive evaluation.

TL;DR: In this article , a prodrug form of YM155, termed aYM155 was developed, which showed potent cell killing activity against a broad panel of patient-derived GBM cancer stem-like cells, as well as EGFR-amplified and EGFR variant III-expressing (EGFRvIII) cell lines.

TL;DR: In this article , a nonporous materials capable of capturing and releasing HCl reversibly in the crystalline solid state was presented, and the reaction is accompanied by a change in color, is fully reversible, and crystallinity is maintained in both molecular materials.