Ana Maria Oliveira Battastini

TL;DR: The results show the neuroprotective effect of lithium and VPA against neuronal death induced by extracellular ATP, probably through a different pathway, and suggest novel uses of these drugs in neurogenerative diseases.

TL;DR: The results confirm the potential of doxazosin as an attractive therapeutic antiglioma agent and tested the neurocitotoxicity ofDoxazOSin in primary astrocytes and organotypic cultures and observed that doxAZosin induced cell death on a small percentage of non-tumor cells.

TL;DR: Novel evidence is shown demonstrating that the pharmacological inhibition of PI3Kγ (phosphatidylinositol 3-kinase) with AS252424, concentration-dependently reduced T24 cell proliferation induced by BK or des-Arg9-BK, which is tempting to suggest that selective kinin antagonists might represent potential alternative therapies for bladder cancer.

TL;DR: The results demonstrate that ATP and ADP hydrolyzing activities increase in parallel from birth until the second postnatal week (about 4-fold), followed by a slight and statistically insignificant increase until the animal reaches adulthood, and the parallel development of both activities strongly suggest that a single enzyme, an ATP diphosphohydrolase, is involved in ATP and adp hydrolysis by the synaptosomal fraction.

TL;DR: An original and focused library of two sets of dihydropyrimidin-2-thiones substituted with N-1 aryl groups derived from monastrol was designed and synthesized in order to discover a more effective Eg5 ligand than the template, leading to the discovery of two original compounds, called 20h and 20e, with an anti-proliferative effects.