Ana Nunes

TL;DR: It is shown that caffeine prevents the maladaptive changes caused by CUS in a manner mimicked by the selective blockade of adenosine A2A receptors (A2AR), suggesting A2AR as candidate targets to alleviate the consequences of chronic stress on brain function.

TL;DR: It is demonstrated that amygdala A2ARs control fear memory and the underlying process of synaptic plasticity in this brain region, which provides a neurophysiological basis for the association between A 2AR polymorphisms and phobia or panic attacks in humans and prompts a therapeutic interest in A2 ARs to manage fear-related pathologies.

TL;DR: A significant amount of information discriminating between multiple neurodegenerative states is conveyed by OCT imaging of the human retina, even when differences in thickness are not yet present, which may allow for simultaneously diagnosing Alzheimer's and Parkinson's diseases.

TL;DR: The results provide the first demonstration of a functional interaction between P2X7R and A2AR controlling microglia reactivity likely involved in behavioral adaptive responses to stress and are illustrative of a cooperation between the two arms of the purinergic system in the control of brain function.

TL;DR: Texture analysis describes a variety of image analysis techniques that quantify the variation in intensity and pattern as discussed by the authors, which can be used as a biomarker of disease onset and progression in biological tissues and organs.