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Ana Risco
Researcher at Spanish National Research Council
Publications - 14
Citations - 846
Ana Risco is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Kinase & Protein kinase A. The author has an hindex of 11, co-authored 14 publications receiving 682 citations. Previous affiliations of Ana Risco include University of Extremadura.
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Journal ArticleDOI
Differential activation of p38MAPK isoforms by MKK6 and MKK3
Gaëlle Rémy,Ana Risco,Francisco Inesta-Vaquera,Bárbara González-Terán,Guadalupe Sabio,Guadalupe Sabio,Roger J. Davis,Ana Cuenda +7 more
TL;DR: It is shown that MKK3 and MKK6 are both essential for the activation of p38gamma and p38beta induced by environmental stress, whereas MKK 6 is the major p38Gamma activator in response to TNFalpha.
Journal ArticleDOI
p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation
Ana Risco,Carlos del Fresno,Agnes Mambol,Dayanira Alsina-Beauchamp,Kirsty F. MacKenzie,Huei-Ting Yang,Domingo F. Barber,Carmen Morcelle,J. Simon C. Arthur,Steven C. Ley,Carlos Ardavín,Ana Cuenda +11 more
TL;DR: Deletion of p38γ and p38δ impaired the innate immune response to lipopolysaccharide (LPS), a Toll-like receptor 4 (TLR4) ligand, by blocking the extracellular signal-regulated kinase 1/2 (ERK1/2) activation in macrophages and dendritic cells.
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Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A
Alfonso Mora,Guadalupe Sabio,Ana Risco,Ana Cuenda,Juan C. Alonso,Germán Soler,Francisco Centeno +6 more
TL;DR: It is hypothesised that the neuroprotective action of lithium may be due to the inhibition of the PP2A activation by apoptotic stimuli.
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Implication of Akt, ERK1/2 and alternative p38MAPK signalling pathways in human colon cancer cell apoptosis induced by green tea EGCG.
Maria Isabel Cerezo-Guisado,Maria Isabel Cerezo-Guisado,Rafal Zur,M. J. Lorenzo,Ana Risco,Miguel A. Martín-Serrano,Alberto Álvarez-Barrientos,Ana Cuenda,Francisco Centeno +8 more
TL;DR: Using a combination of kinase inhibitors, it is found that EGCG-induced cell death is partially blocked by inhibiting Akt, ERK1/2 or alternative p38MAPK activity, suggesting potential use of this compound as chemotherapeutic agent for colon cancer treatment.
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Pro-Oncogenic Role of Alternative p38 Mitogen-Activated Protein Kinases p38γ and p38δ, Linking Inflammation and Cancer in Colitis-Associated Colon Cancer
Paloma del Reino,Dayanira Alsina-Beauchamp,Alejandra Escós,Ma Isabel Cerezo-Guisado,Ana Risco,Noelia Aparicio,Rafal Zur,Marian Fernandez-Estevez,Elena Collantes,Jose Montans,Ana Cuenda +10 more
TL;DR: The results establish that p38γ and p38δ are central to colitis-associated colon cancer formation through regulation of hematopoietic cell response to injury, and validate p38αMAPK (MAPK14) and p 38δ as potential targets for cancer therapy.