Showing papers by "Ananda S. Prasad published in 2006"
TL;DR: In vitro addition of zinc to MNCs for correction of gene expression of IL-2 in humans may be used as a specific test for zinc deficiency, although currently no known specific laboratory test exists for the diagnosis of zinc deficiency in humans.
51 citations
TL;DR: The data indicate that not only low level of zinc, but also high levels of zinc decrease Th1 function, as higher concentration of zinc adversely affects T-cell immune response.
37 citations
TL;DR: A novel mutation in a Tunisian family in which a chain termination codon in exon 3 yielded a truncated ZIP4 zinc transporter protein is described, which causes acrodermatitis enteropathica.
22 citations
TL;DR: Investigating the effects of low zinc-induced alterations in gene expression in a single lymphoid cell line in the absence of influences from growth factors and/or cytokines generated by other cell types also being affected by low zinc status provides evidence for a shift in geneexpression of molecules that would increase lymphoid responses to myeloid driven pathways during periods of zinc deficiency even in the presence of myeloids-derived stimuli.
19 citations
TL;DR: In conclusion, genistein supplementation to the basal diet improved digestibility of CP, DM and ash and levels of Ca and P and bone mineralization in quails reared under heat stress conditions.
Abstract: Genistein is a powerful antioxidant and plays a role in calcium and bone metabolism. We evaluated the efficacy of dietary supplementation with genistein on the nutrient use and mineral concentrations in tibia and serum of quails reared at high environmental temperature (34°C). Two hundred and forty Japanese quails (10 days old) were randomly assigned to 8 treatment groups consisting of 10 replicates of 3 birds. The birds were kept in a temperature-controlled room at 22°C (Thermoneutral, TN groups) or 34°C (for 8 h/d; 09.00 am-05.00 pm; Heat stress, HS groups). Birds were fed either a basal diet (TN and HS) or the basal diet supplemented with 200, 400 or 800 mg of genistein/kg of diet. Heat exposure decreased apparent nutrient digestibility and bone mineralization when the basal diet was fed (P<0.001). Apparent digestibility of dry matter (DM) (P<0.05), crude protein (CP) (P<0.05) and ash (P<0.01) was significantly improved by genistein supplementation. However, this improvement was not in direct proportion to increased doses of supplement since there was no difference when diets included either 400 or 800 mg genistein/kg of diet (P<0.05) in birds reared under heat stress. The amounts of Ca, P, Mg, Mn, Zn, Fe and Cu in the excreta decreased (P<0.01), while Ca, P, Mg, Mn, Zn and Cu concentrations in tibia ash increased in quails reared under heat stress conditions (P<0.01) with genistein supplementation. Ca and P concentrations in tibia ash were also increased in birds kept under thermoneutral conditions with genistein supplementation. Increased serum alkaline phosphatase activity (P<0.01) was associated with increasing dietary genistein in all groups. In conclusion, genistein supplementation to the basal diet improved digestibility of CP, DM and ash and levels of Ca and P and bone mineralization in quails reared under heat stress conditions.
11 citations
TL;DR: Zinc supplementation decreased TNF-induced NF-κB DNA binding (a biomarker of oxidative stress) by EMSA in isolated MNC, compared to placebo, and increased the relative level of IL-2 mRNA in PHA-stimulated MNC compared toplace, suggesting that zinc supplementation may be beneficial in SCD patients.
1 citations