Anda M. Vlad

TL;DR: It is reported for the first time that distinct plasma miRNA expression patterns may serve as highly specific and sensitive diagnostic biomarkers to discriminate between healthy, endometriosis, and EAOC cases.

TL;DR: This work has identified a new mechanism by which potentially immunogenic glycoprotein tumor Ags, such as MUC1, fail to stimulate strong immune responses, and shows that a 140-aa-long synthetic peptide is very efficiently processed by dendritic cells.

TL;DR: It is shown that DCs endocytose MUC1 glycopeptides, transport them to acidic compartments, process them into smaller peptides, and present them on major histocompatability complex (MHC) class II molecules without removing the carbohydrates, suggesting that a much broader repertoire of T cells could be elicited against M UC1 and other glycoproteins than expected based only on their peptide sequences.

TL;DR: Cisplatin upregulates PD-L1 expression in vitro and in vivo, demonstrating a dual, paradoxical immune modulatory effect and supporting the rationale for combination with immune checkpoint blockade.