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André Lochter
Researcher at Lawrence Berkeley National Laboratory
Publications - 17
Citations - 3685
André Lochter is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Extracellular matrix & Basement membrane. The author has an hindex of 16, co-authored 17 publications receiving 3584 citations. Previous affiliations of André Lochter include University of California, San Francisco.
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Journal ArticleDOI
The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis.
Mark D. Sternlicht,André Lochter,Carolyn J. Sympson,Bing Huey,Jean-Philippe Rougier,Joe W. Gray,Daniel Pinkel,Mina J. Bissell,Zena Werb +8 more
TL;DR: P phenotypically normal mammary epithelial cells with tetracycline-regulated expression of MMP3/stromelysin-1 (Str1) form epithelial glandular structures in vivo without Str1 but form invasive mesenchymal-like tumors with Str1, indicating that Str1 influences tumor initiation and alters neoplastic risk.
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Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells
TL;DR: It is demonstrated that inappropriate expression of SL-1 initiates a cascade of events that may represent a coordinated program leading to loss of the differentiated epithelial phenotype and gain of some characteristics of tumor cells.
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The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells
TL;DR: Results provide direct evidence for a crucial role of MMPs in branching in mammary epithelium and suggest that, in addition to epimorphin, MMP activity is a minimum requirement for branching morphogenesis in the mammary gland.
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Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-β Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis
Morten A. Karsdal,Lykke Larsen,Michael T. Engsig,Henriette Lou,Mercedes Ferreras,André Lochter,Jean-Marie Delaissé,Niels T. Foged +7 more
TL;DR: It is suggested that MMP-activated TGF-β maintains osteoblast survival during trans-differentiation into osteocytes by a p44/42-dependent pathway.
Journal ArticleDOI
Proteinases in bone resorption: obvious and less obvious roles
Jean-Marie Delaissé,Michael T. Engsig,Vincent Everts,Maria del Carmen Ovejero,Mercedes Ferreras,Leif R. Lund,Thiennu H. Vu,Zena Werb,Bent Winding,André Lochter,Morten A. Karsdal,Tine Troen,Tove Kirkegaard,Thomas Lenhard,Anne-Marie Heegaard,Lynn Neff,Roland Baron,Niels T. Foged +17 more
TL;DR: This review shows that the need of proteinases for bone resorption is critical not only because they are required for the solubilization of bone matrix, but alsoBecause they are key components of the mechanism that determines where and when bone Resorption will be initiated.