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André Simões-Pires
Researcher at Universidade Federal do Rio Grande do Sul
Publications - 8
Citations - 413
André Simões-Pires is an academic researcher from Universidade Federal do Rio Grande do Sul. The author has contributed to research in topics: Oxidative stress & Superoxide dismutase. The author has an hindex of 7, co-authored 8 publications receiving 356 citations.
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Curcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacological efficacy of curcumin in glioma treatment
Alfeu Zanotto-Filho,Karine Coradini,Elizandra Braganhol,Rafael Schröder,Claudia M. Oliveira,André Simões-Pires,Ana Maria Oliveira Battastini,Adriana Raffin Pohlmann,Silvia Stanisçuaski Guterres,Cassiano Mateus Forcelini,Ruy Carlos Ruver Beck,José Cláudio Fonseca Moreira +11 more
TL;DR: The data suggest that the nanoencapsulation of curcumin in LNC is an important strategy to improve its pharmacological efficacy in the treatment of gliomas.
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The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma
Alfeu Zanotto-Filho,Elizandra Braganhol,Maria Isabel Albano Edelweiss,Guilherme Antônio Behr,Rafael Fernandes Zanin,Rafael Schröder,André Simões-Pires,Ana Maria Oliveira Battastini,José Cláudio Fonseca Moreira +8 more
TL;DR: The mechanisms underlying apoptosis, selectivity, efficacy and safety of curcumin from in vitro and in vivo models of glioblastomas are examined and data presented here suggestCurcumin as a potential agent for therapy of GBMs.
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Investigation of the in vitro and ex vivo acetylcholinesterase and antioxidant activities of traditionally used Lycopodium species from South America on alkaloid extracts.
Eduardo Luis Konrath,Bruna Medeiros Neves,Paula Lunardi,Carolina dos Santos Passos,André Simões-Pires,María Gabriela Ortega,Carlos Alberto Gonçalves,José Luis Cabrera,José Cláudio Fonseca Moreira,Amélia T. Henriques +9 more
TL;DR: This study showed that the biological properties of the folk medicinal plants LyCopodium clavatum and Lycopodium thyoides include AChE inhibitory activity and antioxidant effects, two possible mechanisms of action in Alzheimer's related processes.
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Increased cerebral oxidative damage and decreased antioxidant defenses in ovariectomized and sham-operated rats supplemented with vitamin A.
Guilherme Antônio Behr,Guilherme Antônio Behr,Carlos Eduardo Schnorr,André Simões-Pires,Leonardo Lisbôa da Motta,Benicio N. Frey,José Cláudio Fonseca Moreira +6 more
TL;DR: Vitamin A may induce a pro-oxidant state in discrete brain regions of sham-operated and OVX rats, and the results suggest some caution regarding the use of high doses of vitamin A supplementation during menopause.
Journal ArticleDOI
Vitamin A supplementation in rats under pregnancy and nursing induces behavioral changes and oxidative stress upon striatum and hippocampus of dams and their offspring.
Carlos Eduardo Schnorr,Maurilio da Silva Morrone,André Simões-Pires,Ricardo Fagundes da Rocha,Guilherme Antônio Behr,José Cláudio Fonseca Moreira +5 more
TL;DR: Vitamin A supplementation during pregnancy and nursing increased superoxide dismutase/catalase (SOD/CAT) ratio and oxidative damage in maternal and offspring striatum and hippocampus and induced behavioral alterations is investigated.