A
Andrea G. Bodnar
Researcher at Bermuda Institute of Ocean Sciences
Publications - 42
Citations - 9409
Andrea G. Bodnar is an academic researcher from Bermuda Institute of Ocean Sciences. The author has contributed to research in topics: Sea urchin & Lytechinus variegatus. The author has an hindex of 23, co-authored 41 publications receiving 9068 citations. Previous affiliations of Andrea G. Bodnar include Bermuda Biological Station for Research & University of California, San Diego.
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Journal ArticleDOI
Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
TL;DR: In this article, two telomerase-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encoding the human telomere catalytic subunit.
Journal ArticleDOI
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
Scott L. Weinrich,Ron Pruzan,Libin Ma,Michel M. Ouellette,Valeric M. Tesmer,Shawn E. Holt,Andrea G. Bodnar,Serge Lichtsteiner,Nam Woo Kim,James B. Trager,Rebecca D. Taylor,Ruben Carlos,William H. Andrews,Woodring E. Wright,Jerry W. Shay,Calvin B. Harley,Gregg B. Morin +16 more
TL;DR: In vitro transcription and translation of hTRT when co-synthesized or mixed with hTR reconstitutes telomerase activity that exhibits enzymatic properties like those of the native enzyme.
Journal ArticleDOI
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
Xu-Rong Jiang,Gretchen S. Jimenez,Edwin Chang,Maria Frolkis,Brenda Kusler,Marijke Sage,Michelle Beeche,Andrea G. Bodnar,Geoffrey M. Wahl,Thea D. Tlsty,Choy-Pik Chiu +10 more
TL;DR: It is reported that at twice the normal number of population doublings, telomerase-expressing human skin fibroblasts and retinal pigment epithelial cells (RPE-hTERT) retain normal growth control in response to serum deprivation, high cell density, G1 or G2 phase blockers and spindle inhibitors.
Journal ArticleDOI
A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase.
TL;DR: It is concluded that a novel PTS is identified that functions at amino‐terminal or internal locations and is distinct from the C-terminal PTS, which implies the existence of two different routes for targeting proteins into the peroxisomal matrix.
Journal ArticleDOI
Human endothelial cell life extension by telomerase expression.
Jiwei Yang,Edwin Chang,Athena M. Cherry,Charles D. Bangs,Y. Oei,Andrea G. Bodnar,A. Bronstein,Choy-Pik Chiu,G. S. Herron +8 more
TL;DR: It is reported for the first time that hTERT expression in these life-extended vascular cells does not affect their differentiated and functional phenotype and that these cells maintain their angiogenic potential in vitro.