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William H. Andrews
Researcher at Geron Corporation
Publications - 23
Citations - 6099
William H. Andrews is an academic researcher from Geron Corporation. The author has contributed to research in topics: Telomerase reverse transcriptase & Telomerase. The author has an hindex of 14, co-authored 23 publications receiving 5976 citations. Previous affiliations of William H. Andrews include University of Colorado Boulder & Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
The RNA component of human telomerase
Junli Feng,Walter Funk,Sy Shi Wang,Scott L. Weinrich,Ariel A. Avilion,Choy-Pik Chiu,Robert Adams,Edwin Chang,Richard C. Allsopp,Jinghua Yu,Siyuan Le,Michael D. West,Calvin B. Harley,William H. Andrews,Carol W. Greider,Bryant Villeponteau +15 more
TL;DR: Human cell lines that expressed hTR mutated in the template region generated the predicted mutant telomerase activity, and cells transfected with an antisense hTR lost telomeric DNA and began to die after 23 to 26 doublings.
Journal ArticleDOI
Telomerase catalytic subunit homologs from fission yeast and human
Toru Nakamura,Gregg B. Morin,Gregg B. Morin,Karen B. Chapman,Karen B. Chapman,Scott L. Weinrich,Scott L. Weinrich,William H. Andrews,William H. Andrews,Joachim Lingner,Joachim Lingner,Calvin B. Harley,Calvin B. Harley,Thomas R. Cech,Thomas R. Cech +14 more
TL;DR: In this paper, the homologous genes from the fission yeast Schizosaccharomyces pombe and human are identified and the proposed telomerase catalytic subunits represent a deep branch in the evolution of reverse transcriptases.
Journal ArticleDOI
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
Scott L. Weinrich,Ron Pruzan,Libin Ma,Michel M. Ouellette,Valeric M. Tesmer,Shawn E. Holt,Andrea G. Bodnar,Serge Lichtsteiner,Nam Woo Kim,James B. Trager,Rebecca D. Taylor,Ruben Carlos,William H. Andrews,Woodring E. Wright,Jerry W. Shay,Calvin B. Harley,Gregg B. Morin +16 more
TL;DR: In vitro transcription and translation of hTRT when co-synthesized or mixed with hTR reconstitutes telomerase activity that exhibits enzymatic properties like those of the native enzyme.
Journal ArticleDOI
Cataloging altered gene expression in young and senescent cells using enhanced differential display
Maarten H.K. Linskens,Junli Feng,William H. Andrews,Brett E. Enlow,Shahin M. Saati,Leath A. Tonkin,Walter Funk,Bryant Villeponteau +7 more
TL;DR: Improved version of differential display, which is modified to enhance reproducibility and to facilitate sequencing and cloning, is reported here and generated and verified a catalog of genes that are differentially expressed between young and senescent human diploid fibroblasts.
Patent
Human telomerase catalytic subunit
Thomas R. Cech,Joachim Lingner,Toru Nakamura,Karen B. Chapman,Gregg B. Morin,Calvin B. Harley,William H. Andrews +6 more
TL;DR: The peptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of disease such as cancers as discussed by the authors.