E
Edwin Chang
Researcher at Stanford University
Publications - 57
Citations - 7803
Edwin Chang is an academic researcher from Stanford University. The author has contributed to research in topics: Endothelial stem cell & Stem cell. The author has an hindex of 24, co-authored 54 publications receiving 7084 citations. Previous affiliations of Edwin Chang include Geron Corporation & McMaster University.
Papers
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Journal ArticleDOI
The RNA component of human telomerase
Junli Feng,Walter Funk,Sy Shi Wang,Scott L. Weinrich,Ariel A. Avilion,Choy-Pik Chiu,Robert Adams,Edwin Chang,Richard C. Allsopp,Jinghua Yu,Siyuan Le,Michael D. West,Calvin B. Harley,William H. Andrews,Carol W. Greider,Bryant Villeponteau +15 more
TL;DR: Human cell lines that expressed hTR mutated in the template region generated the predicted mutant telomerase activity, and cells transfected with an antisense hTR lost telomeric DNA and began to die after 23 to 26 doublings.
Journal ArticleDOI
Microarray analysis of replicative senescence
TL;DR: Several genes that are constitutively overexpressed in senescent fibroblasts are regulated during the cell cycle in early-passage cells, suggesting that senescent cells are locked in an activated state that mimics the early remodeling phase of wound repair.
Journal ArticleDOI
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
Xu-Rong Jiang,Gretchen S. Jimenez,Edwin Chang,Maria Frolkis,Brenda Kusler,Marijke Sage,Michelle Beeche,Andrea G. Bodnar,Geoffrey M. Wahl,Thea D. Tlsty,Choy-Pik Chiu +10 more
TL;DR: It is reported that at twice the normal number of population doublings, telomerase-expressing human skin fibroblasts and retinal pigment epithelial cells (RPE-hTERT) retain normal growth control in response to serum deprivation, high cell density, G1 or G2 phase blockers and spindle inhibitors.
Journal ArticleDOI
Telomere length and replicative aging in human vascular tissues
Edwin Chang,Calvin B. Harley +1 more
TL;DR: Observations extend the use of telomere size as a marker for the replicative history of cells and are consistent with a role for focal replicative senescence in cardiovascular diseases.
Journal ArticleDOI
Human endothelial cell life extension by telomerase expression.
Jiwei Yang,Edwin Chang,Athena M. Cherry,Charles D. Bangs,Y. Oei,Andrea G. Bodnar,A. Bronstein,Choy-Pik Chiu,G. S. Herron +8 more
TL;DR: It is reported for the first time that hTERT expression in these life-extended vascular cells does not affect their differentiated and functional phenotype and that these cells maintain their angiogenic potential in vitro.