Andrea L. Richardson

TL;DR: The paradoxical relationship between extreme CIN and cancer outcome in the ER-negative cohorts may explain why prognostic expression signatures, reflecting tumor CIN status, fail to predict outcome in this subgroup.

TL;DR: A novel process by which certain luminal breast cancer cells and patient tumor specimens establish a systemic macroenvironment that supports outgrowth of otherwise-indolent disseminated tumors is discovered, highlighting the macroenvironment as an important component of disease progression that can be exploited to more accurately identify patients who would benefit from adjuvant therapy.

TL;DR: Using a model system of paired breast cancer cell lines, it is found that coactivation of STAT5 and STAT3 leads to decreased proliferation and increased sensitivity to the chemotherapeutic drugs paclitaxel and vinorelbine compared with cells that have only STAT3 activation.

TL;DR: Correlation of the technical quality of the biopsy, imaging features, and pathologic findings resulted in 96 surgical excisions and 16 repeat biopsies of lesions initially considered nonmalignant.

TL;DR: It is hypothesized that dermcidin (DCD) may play a role in tumorigenesis by means of enhancing cell growth and survival in a subset of breast carcinomas.